Triiodide Ion-Selective Polymeric Membrane Electrode Based on a Ketoconazole-Triiodide Ion Pair

Abstract

A new triiodide ion‐selective PVC membrane sensor based on diprotonated ketoconazole‐triiodide, as (KCH2)(I3)2, ion pair, was proposed. The electrode has a linear dynamic range between 2.0×10−3 and 7.0×10−6 M with a Nernstian slope of −59.9±1.6 mV per decade and a detection limit of 3.0×10−6 M. The potentiometric response is independent of the pH of the solution in the pH range 2–8.5. The electrode can be used for at least 3 months without any considerable divergence in potential. It was applied as indicator electrode in potentiometric titration of ascorbic acid, hydroquinone from pharmaceutical preparations and triiodide ions in solution. The proposed triiodide membrane sensor was also used in development of a new, simple, fast, inexpensive and precise method for the determination of Ketoconazole in formulations.

A New Selective Membrane Electrode for Oxalate Based on N,N'-Bis(salicylidene)-2,2-dimethylpropane-1,3-diamine Ni(II)

“…It is well known that the sensitivity, linearity and selectivity, obtained for a given ionophore, depends significantly on the membrane composition, nature and the amount of additive used. 2,[27][28][29][30][31] The percentage of membrane solvent in poly (vinyl chloride) membranes and the membrane solutions for micro-electrodes is very high (60-90 wt.%). Hence, the membrane solvent has to exhibit excellent plasticizer properties for use in solvent polymeric membranes.…”

Charge-Transfer Triiodide Ion-Selective Electrode Based on 7,16-Dibenzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

“…Among different anion carriers used for this purpose, 4 the use of metalloporphyrins, [5][6][7][8][9][10] metal complexes, 11,12 and organometalic compounds 13,14 as ionophores in solvent polymeric membrane electrodes are well known to induce potentiometric anion selectivity sequences that differ significantly from the classical Hofmeister pattern. [5][6][7][8][9][10][11][12][13][14] Despite the need for a triiodide ion-selective electrode for the determination of iodide and triiodide ion in many medical, 17,18 juice (as ascorbic acid in orange juice) 20 and environmental samples (such as dissolved O2 in water), [15][16][17][18][19][20][21][22][23] to date there have been limited reports on an I3 -ion-selective electrode in the literature. [17][18][19]22,23 Furthermore, it is interesting to note that, to the best of our knowledge, there is one literature report concerning the use of charge-transfer complexes of crown ethers for preparing an ion-selective electrode.…”

“…[5][6][7][8][9][10][11][12][13][14] Despite the need for a triiodide ion-selective electrode for the determination of iodide and triiodide ion in many medical, 17,18 juice (as ascorbic acid in orange juice) 20 and environmental samples (such as dissolved O2 in water), [15][16][17][18][19][20][21][22][23] to date there have been limited reports on an I3 -ion-selective electrode in the literature. [17][18][19]22,23 Furthermore, it is interesting to note that, to the best of our knowledge, there is one literature report concerning the use of charge-transfer complexes of crown ethers for preparing an ion-selective electrode. 23 In this article, we report on a highly selective PVC-based membrane sensor for the I3 -anion based on a charge-transfer complex between iodine and 7,16-dibenzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan (DBZDA18C6), formulated as (DBZDA18C6·I + )I3 -, as suitable sensing material.…”

Highly Selective Triiodide Polymeric Membrane Electrode Based on Tetra(p-chlorophenyl)porphyrinato Manganese (Ⅲ) Acetate

“…We have recently introduced two triiodide PVC membrane sensors based on a charge-transfer complex of I 2 with 2,4,6,8-tetraazabicyclo-[3.3.0]octane 21 and ketoconazole-triodide ion pair complex. 22 In this paper tetra(p-chlorophenyl)porphyrinato manganese (III) acetate (I) is incorporated into plasticized PVC membranes containing 2-nitrophenyloctyl ether and tetrabutylammonium bromide to prepare electrodes with substantially improved selectivity towards the triiodide ion.…”