Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis

Abstract

Introduction: Non-thyroidal illness syndrome (NTIS) is one of the signs for poor prognosis of cerebral infarction (CI), but its risk factors had never been explored. In this study, we analyzed the potential effect of collateral circulation on prognosis prediction of triiodothyronine for large artery atherosclerosis cerebral infarction (LAA-CI) patients. Material and methods: Clinical data of CI patients between 2012 and 2014 were collected. Imaging inspection was used for determining TOAST classification and evaluating collateral circulation. One-year follow-up was conducted for mRS score by telephone. Results: T3 level in the NTIS group (p = 0.001) was significantly decreased while TSH level (p < 0.001) was increased. Patients in the NTIS group had a poorer prognosis (p = 0.008) and the main reason was the high mortality (p = 0.002). NTIS predicted poor collateral circulation (p = 0.026) and good collateral circulation tended to be less likely concomitant with NTIS (p = 0.001). Logistic regression analysis showed that triiodothyronine concentrations (OR = 4.760, 95% CI: 1.981-11.456, p < 0.001) were positively correlated with but advanced age (OR = 0.756, 95% CI: 0.645-0.886, p = 0.001) negatively with opening of collateral circulation. Conclusions: Poor opening of collateral circulation was likely to mediate the prediction of NTIS for prognosis of LAA-CI patients.

T3 as predictor of mortality in any cause non-critically ill patients

“…Treatment of low T3 has proven to be non-efficient so far in preventing poor outcomes ( 46 , 47 , 48 ). However, some investigators suggest that it might be possible to reverse the primary cause of thyroid hormone metabolism dysfunction in specific populations, either by hormonal supplementation or by correction of the underlying disease metabolic alterations ( 49 , 50 , 51 , 52 , 53 , 54 , 55 ). The results here reported acknowledged that T3 levels impact the prognosis of general hospitalized patients.…”

Effects of different rehabilitation training on balance function in stroke patients: a systematic review and network meta-analysis

“…Therefore, it is important to seek effective ways to improve the balance function of patients. Pharmacological treatment is usually used to improve the patient’s overall function, with little mention of single symptom improvement [ 8 ], while surgical treatment requires strict surgical indications [ 9 ] and is not the preferred option in the non-acute phase.…”