Streptococcus gallolyticus
subspecies
pasteurianus
, formerly classified as
S. bovis
biotype II/2 until 2003, is a rare cause of infant meningitis. Over the past 2 decades, only a few individual case reports and limited case series exist in the English-language literature. Moreover, the pathogenesis of
S. gallolyticus
subsp.
pasteurianus
meningitis in infants is unclear. Here we report a case of meningitis in a 6-week-old infant with hypothyroidism and preceding diarrhea. In this case,
S. gallolyticus
was cultured from cerebrospinal fluid, and then
S. gallolyticus
subspecies
pasteurianus
was identified by metagenomic next-generation Sequencing. The infant recovered uneventfully after a 4-week antibiotic course with ceftriaxone and vancomycin. Then combined with the literature of
S. gallolyticus
subsp.
pasteurianus
meningitis in infants, we discuss the possible etiology.