TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1

Wei, Jianwei; Wang, Li; Zhang, Yuyan; Sun, Ting; Zhang, Cai; Hu, Zhonglan; Zhou, Lijuan; Liu, Xianzhi; Wan, Junhu; Ma, Liwei

doi:10.1038/s41388-023-02717-3

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Protein Degradation In Ferroptosis1

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2023

2025

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Cited by 8 publications

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“…Additionally, KEAP1 degradation is regulated by the UPS, affecting the ferroptosis process. The E3 ubiquitin ligase TRIM25 promotes KEAP1 ubiquitination, inducing temozolomide resistance in glioma cells by inhibiting ferroptotic cell death [ 157 ]. These mechanisms collectively oversee and adapt the antioxidant system to modulate ferroptosis.…”

Section: Protein Degradation In Ferroptosismentioning

confidence: 99%

Protein modification and degradation in ferroptosis

Wang,

Yan,

Liu

et al. 2024

Redox Biology

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Section: Protein Degradation In Ferroptosismentioning

confidence: 99%

Protein modification and degradation in ferroptosis

Wang,

Yan,

Liu

et al. 2024

Redox Biology

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Ferroptosis: Potential opportunities for natural products in cancer therapy

Nie,

Shen,

Zhou

et al. 2023

Phytotherapy Research

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Cancer cells often exhibit defects in the execution of cell death, resulting in poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form of programmed cell death characterized by intracellular iron overload and lipid peroxidation in the cell membrane. Increasing evidence suggests that ferroptosis is closely associated with a wide variety of physiological and pathological processes, particularly in cancer. Notably, various bioactive natural products have been shown to induce the initiation and execution of ferroptosis in cancer cells, thereby exerting anticancer effects. In this review, we summarize the core regulatory mechanisms of ferroptosis and the multifaceted roles of ferroptosis in cancer. Importantly, we focus on natural products that regulate ferroptosis in cancer cells, such as terpenoids, polyphenols, alkaloids, steroids, quinones, and polysaccharides. The clinical efficacy, adverse effects, and drug–drug interactions of these natural products need to be evaluated in further high‐quality studies to accelerate their application in cancer treatment.

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