TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells

Dai, Ying; Liu, Ying; Cheng, Ran; Gao, Jie; Li, Yanyang; Lou, Chunyan

doi:10.1016/j.biopha.2018.02.057

Cited by 22 publications

(12 citation statements)

References 30 publications

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“…FGF members have showed to promote not only fibroblast proliferation but also migration and differentiation through binding to and activating fibroblast growth factor receptors, thereby having its application in tissue regeneration (Yun et al, 2010 ). Besides, HGF and PDGF-BB are important multifunctional growth factors for cell proliferation and mobility (Taniguchi et al, 2004 ; De Donatis et al, 2008 ; Sun et al, 2012 ; Gonzalez et al, 2017 ; Dai et al, 2018 ). However, TGF-β that is reported to regulate fibroblast proliferation through miR-21 modulating PTEN/AKT signaling pathway (Liu et al, 2016 ) or to induce ERK/MAPK signaling pathway to enhance migration of endometrial stromal cells (Liu et al, 2019 ) was not detected in BMMSC- and ADMSC-derived exosomes in this study.…”

Section: Discussionmentioning

confidence: 99%

Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition

Hoang

Nguyen

et al. 2020

Front. Mol. Biosci.

119

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Exosomes are nano-scale and closed membrane vesicles which are promising for therapeutic applications due to exosome-enclosed therapeutic molecules such as DNA, small RNAs, proteins and lipids. Recently, it has been demonstrated that mesenchymal stem cell (MSC)-derived exosomes have capacity to regulate many biological events associated with wound healing process, such as cell proliferation, cell migration and blood vessel formation. This study investigated the regenerative potentials for cutaneous tissue, in regard to growth factors associated with wound healing and skin cell proliferation and migration, by exosomes released from primary MSCs originated from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) under serum-and xeno-free condition. We found crucial wound healing-mediated growth factors, such as vascular endothelial growth factor A (VEGF-A), fibroblast growth factor 2 (FGF-2), hepatocyte growth factor (HGF), and platelet-derived growth factor BB (PDGF-BB) in exosomes derived from all three MSC sources. However, expression levels of these growth factors in exosomes were influenced by MSC origins, especially transforming growth factor beta (TGF-β) was only detected in UCMSC-derived exosomes. All exosomes released by three MSCs sources induced keratinocyte and fibroblast proliferation and migration; and, the induction of cell migration is a dependent manner with the higher dose of exosomes was used (20 µg), the faster migration rate was observed. Additionally, the influences of exosomes on cell proliferation and migration was associated with exosome origins and also target cells of exosomes that the greatest induction of primary dermal fibroblasts belongs to BMMSC-derived exosomes Hoang et al. Mesenchymal Stem Cell-Derived Exosomes and keratinocytes belongs to UCMSC-derived exosomes. Data from this study indicated that BMMSCs and UCMSCs under clinical condition secreted exosomes are promising to develop into therapeutic products for wound healing treatment.

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Section: Discussionmentioning

confidence: 99%

Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition

Hoang

Nguyen

et al. 2020

Front. Mol. Biosci.

119

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“…The analysis of biological pathways suggested that the genes of the Skyblue module in the asthma-specific are significantly associated with NF-kB, Wnt, Toll-like receptor, and transforming growth factor (TGF)-beta signaling pathways. These pathways are involved in the inflammation of the respiratory tract, immune system, and chronic inflammatory diseases (Li et al 2018;Zhang et al 2018;Dai et al 2018). In the Skyblue module, eight hub DEGs including STX5, SLC35B2, RNPEPL1, RBM42, PPP6R2, MED22, EML3, and TRIM41 are novel for asthma.…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

Maghsoudloo

Jamalkandi²,

Najafi³

et al. 2020

Mol Med

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Background: asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious pulmonary diseases that contain common and unique characteristics. Therefore, the identification of biomarkers that differentiate these diseases is of importance for preventing misdiagnosis. In this regard, the present study aimed to identify the disorders at the early stages, based on lung transcriptomics data and drug-target interactions. Methods: To this end, the differentially expressed genes were found in each disease. Then, WGCNA was utilized to find specific and consensus gene modules among the three diseases. Finally, the disease-disease similarity was analyzed, followed by determining candidate drug-target interactions. Results: The results confirmed that the asthma lung transcriptome was more similar to COPD than IPF. In addition, the biomarkers were found in each disease and thus were proposed for further clinical validations. These genes included RBM42, STX5, and TRIM41 in asthma, CYP27A1, GM2A, LGALS9, SPI1, and NLRC4 in COPD, ATF3, PPP1R15A, ZFP36, SOCS3, NAMPT, and GADD45B in IPF, LRRC48 and CETN2 in asthma-COPD, COL15A1, GIMAP6, and JAM2 in asthma-IPF and LMO7, TSPAN13, LAMA3, and ANXA3 in COPD-IPF. Finally, analyzing drug-target networks suggested anti-inflammatory candidate drugs for treating the above mentioned diseases. Conclusion: In general, the results revealed the unique and common biomarkers among three chronic lung diseases. Eventually, some drugs were suggested for treatment purposes.

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“…TRIM37 was the second member of the TRIM family (after TRIM5α) to be described as having anti-HIV-1 activity as its overexpression induced decreased viral replication and viral DNA synthesis [38]. TRIM37 was also shown to be involved in airway smooth muscle cell (ASMC) proliferation and migration, and thus in the progression of asthma [39]. TRIM37 expression was significantly decreased in proliferating airway smooth muscle cells, while overexpression of TRIM37 suppressed PDGF-BB-induced proliferation and migration by suppressing the Wnt/β-catenin signaling pathway, with repercussions in asthma.…”

Section: Trim37 Variants and The Mulibrey Syndrome An Inflammatormentioning

confidence: 99%

TRIMming down to TRIM37: Relevance to Inflammation, Cardiovascular Disorders, and Cancer in MULIBREY Nanism

Brigant

Meuth

Rochette

et al. 2018

IJMS

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TRIpartite motif (TRIM) proteins are part of the largest subfamilies of E3 ligases that mediate the transfer of ubiquitin to substrate target proteins. In this review, we focus on TRIM37 in the normal cell and in pathological conditions, with an emphasis on the MULIBREY (MUscle-LIver-BRain-EYe) genetic disorder caused by TRIM37 mutations. TRIM37 is characterized by the presence of a RING domain, B-box motifs, and a coiled-coil region, and its C-terminal part includes the MATH domain specific to TRIM37. MULIBREY nanism is a rare autosomal recessive caused by TRIM37 mutations and characterized by severe pre- and postnatal growth failure. Constrictive pericarditis is the most serious anomaly of the disease and is present in about 20% of patients. The patients have a deregulation of glucose and lipid metabolism, including type 2 diabetes, fatty liver, and hypertension. Puzzlingly, MULIBREY patients, deficient for TRIM37, are plagued with numerous tumors. Among non-MULIBREY patients affected by cancer, a wide variety of cancers are associated with an overexpression of TRIM37. This suggests that normal cells need an optimal equilibrium in TRIM37 expression. Finding a way to keep that balance could lead to potential innovative drugs for MULIBREY nanism, including heart condition and carcinogenesis treatment.

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TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells

Cited by 22 publications

References 30 publications

Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition

Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition

Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

TRIMming down to TRIM37: Relevance to Inflammation, Cardiovascular Disorders, and Cancer in MULIBREY Nanism

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