TRIM8 regulates the chemoresistance of colorectal cancer in a p53-dependent manner

Ni, Mingli; Wang, Yuhui; Xie, Ling

doi:10.3892/ol.2016.5256

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemosensitization by TRIM8 was also observed in SW620 and SW480 cells. SW620 and SW480 cells are two different colon cancer cell lines with different levels of TP53 protein [ 115 , 116 ]. SW620 cells have wild-type TP53 protein, whereas SW480 cells lack TP53 protein.…”

Section: Trim8 a Double-edged Sword In Glioblastomamentioning

confidence: 99%

“…However, this was not the case for SW480 cells. Therefore, TRIM8 was shown to increase the susceptibility of CRC cells to the above chemotherapeutic agent in a TP53-dependent manner [ 115 ]. It is probably important to evaluate the tumor suppressive and oncogenic activity of TRIM8 in relation to the molecular status of p53 because, if p53 is mutated, TRIM8 expression is partially oncogenic [ 48 ].…”

Section: Trim8 a Double-edged Sword In Glioblastomamentioning

confidence: 99%

See 1 more Smart Citation

TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt

et al. 2023

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumors in adults. Despite significant breakthroughs in standard treatment, only about 5% of patients survive 5 years or longer. Therefore, much effort has been put into the search for identifying new glioma-associated genes. Tripartite motif-containing (TRIM) family proteins are essential regulators of carcinogenesis. TRIM8, a member of the TRIM superfamily, is abnormally expressed in high-grade gliomas and is associated with poor clinical prognosis in patients with glioma. Recent research has shown that TRIM8 is a molecule of duality (MoD) that can function as both an oncogene and a tumor suppressor gene, making it a “double-edged sword” in glioblastoma development. This characteristic is due to its role in selectively regulating three major cellular signaling pathways: the TP53/p53-mediated tumor suppression pathway, NFKB/NF-κB, and the JAK-STAT pathway essential for stem cell property support in glioma stem cells. In this review, TRIM8 is analyzed in detail in the context of GBM and its involvement in essential signaling and stem cell-related pathways. We also discuss the basic biological activities of TRIM8 in macroautophagy/autophagy, regulation of bipolar spindle formation and chromosomal stability, and regulation of chemoresistance, and as a trigger of inflammation. Graphical Abstract

show abstract

Section: Trim8 a Double-edged Sword In Glioblastomamentioning

confidence: 99%

Section: Trim8 a Double-edged Sword In Glioblastomamentioning

confidence: 99%

TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt

et al. 2023

View full text Add to dashboard Cite

show abstract

“…TRIM8 downregulation was associated with metastatic progression in Larynx Squamous Cell Carcinoma (LSCC), the most frequent neoplasm of the head and neck [ 22 ]. Moreover, TRIM8 downregulation was also found in other tumors such as osteosarcoma cell lines, ColoRectal Cancer (CRC) and Chronic Lymphocytic Leukemia (CLL) [ 23 , 24 ].…”

Section: Trim8 and P53 Pathway: Not Dying But Stoppingmentioning

confidence: 99%

Emerging Roles of TRIM8 in Health and Disease

Marzano

Guerrini

Pesole

et al. 2021

Cells

View full text Add to dashboard Cite

The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. In this review, we analyze the regulation of TRIM8 gene expression and how it is involved in many cell reactions in response to different stimuli such as genotoxic stress and attacks by viruses or bacteria, playing a central role in the immune response and orchestrating various fundamental biological processes such as cell survival, carcinogenesis, autophagy, apoptosis, differentiation and inflammation. Moreover, we show how TRIM8 functions are not limited to ubiquitination, and contrasting data highlight its role either as an oncogene or as a tumor suppressor gene, acting as a “double-edged weapon”. This is linked to its involvement in the selective regulation of three pivotal cellular signaling pathways: the p53 tumor suppressor, NF-κB and JAK-STAT pathways. Lastly, we describe how TRIM8 dysfunctions are linked to inflammatory processes, autoimmune disorders, rare developmental and cardiovascular diseases, ischemia, intellectual disability and cancer.

show abstract

“…In a transcriptome-wide analysis of Larynx Squamous Cell Carcinoma (LSCC), the most frequent neoplasm of the head and neck, TRIM8 down-regulation was found to be associated with metastatic progression suggesting its tumour suppressor role. Moreover, TRIM8 downregulation was also found in other tumours as Glioblastoma Multiforme (GBM), clear cell Renal Cell Carcinoma (ccRCC), anaplastic thyroid cancer (ATC), colorectal cancer (CRC), Chronic lymphocytic leukemia (CLL), and osteosarcoma cell lines [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Accordingly, the restoration of TRIM8 levels in osteosarcoma U2OS cells stably inhibited their capability of forming colonies, confirming the anti-proliferative action of TRIM8 and suggesting its role in cell-cycle control.…”

Section: The Role Of Trim8 In Tumorigenesis: Tumour Suppressor or mentioning

confidence: 99%

TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

Caratozzolo

Marzano

Mastropasqua

et al. 2017

Genes

View full text Add to dashboard Cite

The TRIM8/GERP protein is a member of the TRIM family defined by the presence of a common domain structure composed of a tripartite motif including a RING-finger, one or two B-box domains, and a coiled-coil motif. The TRIM8 gene maps on chromosome 10 within a region frequently found deleted and rearranged in tumours and transcribes a 3.0-kB mRNA. Its expression is mostly ubiquitously in murine and human tissues, and in epithelial and lymphoid cells, it can be induced by IFNγ. The protein spans 551 aa and is highly conserved during evolution. TRIM8 plays divergent roles in many biological processes, including important functions in inflammation and cancer through regulating various signalling pathways. In regulating cell growth, TRIM8 exerts either a tumour suppressor action, playing a prominent role in regulating p53 tumour suppressor activity, or an oncogene function, through the positive regulation of the NF-κB pathway. The molecular mechanisms underlying this dual role in human cancer will be discussed in depth in this review, and it will highlight the challenge and importance of developing novel therapeutic strategies specifically aimed at blocking the pro-oncogenic arm of the TRIM8 signalling pathway without affecting its tumour suppressive effects.

show abstract

TRIM8 regulates the chemoresistance of colorectal cancer in a p53-dependent manner

Cited by 4 publications

References 0 publications

TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt

TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt

Emerging Roles of TRIM8 in Health and Disease

TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

Contact Info

Product

Resources

About