Trimethoprim-Sulfamethoxazole in Brucellosis

Daikos, G. K.; Papapolyzos, N.; Marketos, Nikolaos; Mochlas, Sotirios; Kastanakis, Serafim; Papasteriadis, E.

doi:10.1093/infdis/128.supplement_3.s731

Cited by 38 publications

(8 citation statements)

References 2 publications

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“…[2][3][4][5][6] There are few guidelines for the appropriate duration neurobrucellosis treatment. 25 Recent reports recommend a regimen with a combination of three or four antibiotics for neurobrucellosis. 11 Doxycycline is the preferred tetracycline in neurobrucellosis because its tissue and CNS penetrance is much better and it also has a longer half-life.…”

Section: Brucellosis Is a Common Endemic Infection In Turkeymentioning

confidence: 99%

See 1 more Smart Citation

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region

Ceran¹,

Türkoğlu²,

Erdem³

et al. 2011

Braz J Infect Dis

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Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis is an uncommon complication of this infection. The aim of this study was to present unusual clinical manifestations and to discuss the management and outcome of a series of 18 neurobrucellosis cases. Initial clinical manifestations consist of pseudotumor cerebri in one case, white matter lesions and demyelinating syndrome in three cases, intracranial granuloma in one case, transverse myelitis in two cases, sagittal sinus thrombosis in one case, spinal arachnoiditis in one case, intracranial vasculitis in one case, in addition to meningitis in all cases. Eleven patients were male and seven were female. The most prevalent symptoms were headache (83%) and fever (44%). All patients were treated with rifampicin, doxycycline plus trimethoprim-sulfamethoxazole or ceftriaxone. Duration of treatment (varied 3-12 months) was determined on basis of the CSF response. In four patients presented with left mild sequelae including aphasia, hearing loss, hemiparesis. In conclusion, although mortality is rare in neurobrucellosis, its sequelae are signifi cant. In neurobrucellosis various clinical and neuroradiologic signs and symptoms can be confused with other neurologic diseases. In inhabitants or visitors of endemic areas, neurobrucellosis should be kept in mind in cases that have unusual neurological manifestations.

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Section: Brucellosis Is a Common Endemic Infection In Turkeymentioning

confidence: 99%

“…Rifampicin and co-trimoxazole also offer a good penetration into the CSF. 25 Ciprofl oxacin combined (not solely 26 ) with other antibiotics is as effective as the standard regimen of doxycycline and rifampicin. 27,28 Ceftriaxone also offers good in vitro activity and penetration into the CSF.…”

Section: Brucellosis Is a Common Endemic Infection In Turkeymentioning

confidence: 99%

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region

Ceran¹,

Türkoğlu²,

Erdem³

et al. 2011

Braz J Infect Dis

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show abstract

“…suMMARY 14 children, aged between 15 months and 14 years, with brucellosis were treated with oral rifampicin only (20 mg/kg per day) for 3 weeks. Laboratory diagnosis depended on blood culture (positive for Bracella melitensis in 11 of the cases), serum agglutination, complement-fixation test, and Coombs's test.…”

mentioning

confidence: 99%

Brucellosis treated with rifampicin.

Llorens-Terol

Busquets²

1980

Archives of Disease in Childhood

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“…Monoterapi, direnç görülmesi ve relapslar açısından önerilmez. Dünya Sağlık Örgütü (1986) altı hafta doksisiklin (2x100 mg, oral) + rifampisin (15 mg/kg/oral) kombinasyonunu önermiştir (27)(28)(29) .…”

Section: Tedaviunclassified

Brucellosis

Şimşek¹,

Kantürk²

2016

Okmeydani Medical Journal

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Trimethoprim-Sulfamethoxazole in Brucellosis

Cited by 38 publications

References 2 publications

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region

Brucellosis treated with rifampicin.

Brucellosis

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