Trimethoprim-Sulfamethoxazole Induced Rhabdomyolysis

Ainapurapu, Bujji; Kanakadandi, Uday

doi:10.1097/mjt.0b013e31824567fe

Cited by 8 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results demonstrated significant rhabdomyolysis associations (from strongest to weakest) with daptomycin, cefditoren, cefaclor, erythromycin, norfloxacin, clarithromycin, meropenem, azithromycin, cefdinir, piperacillintazobactam, trimethoprim-sulfamethoxazole, linezolid, and ciprofloxacin. Our results confirmed previously known rhabdomyolysis associations with daptomycin, macrolides, trimethoprimsulfamethoxazole, linezolid, fluoroquinolones, and cefdinir [2][3][4][5][6][7][8][9][10][11][12][13][14]. Meropenem, cefditoren, cefaclor, and piperacillin-tazobactam were found to be associated with rhabdomyolysis, which were not reported in the literature.…”

Section: Discussionsupporting

confidence: 91%

“…A review of 53 cases showed rhabdomyolysis associated with concomitant use of statins and azithromycin [7]. Additionally, case reports indicated that trimethoprim-sulfamethoxazole induced rhabdomyolysis occurred in both immunocompetent and immunocompromised patients [8,9]. There have been case reports linking the use of linezolid to serious cases of rhabdomyolysis [10,11].…”

Section: Ivyspringmentioning

confidence: 99%

See 1 more Smart Citation

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Teng¹,

Baus²,

Wilson³

et al. 2019

Int. J. Med. Sci.

View full text Add to dashboard Cite

Introduction: Daptomycin, macrolides, trimethoprim-sulfamethoxazole, linezolid, fluoroquinolones, and cefdinir are known to be associated with rhabdomyolysis. Other antibiotics may also lead to rhabdomyolysis, but no study has systemically compared rhabdomyolysis associations for many available antibiotics. Objectives: The objective of this study was to evaluate the association between rhabdomyolysis and many available antibiotics using the FDA Adverse Event Report System (FAERS). Methods: FAERS reports from January 1, 2004 to December 31, 2017 were included in the study. The Medical Dictionary for Regulatory Activities (MedDRA) was used to identify rhabdomyolysis cases. Reporting Odds Ratios (RORs) and corresponding 95% confidence intervals (95%CI) for the association between antibiotics and rhabdomyolysis were calculated. An association was considered statistically significant when the lower limit of the 95%CI was greater than 1.0. Results: A total of 2,334,959 reports (including 7,685 rhabdomyolysis reports) were considered, after inclusion criteria were applied. Daptomycin had the greatest proportion of rhabdomyolysis reports, representing 5.5% of all daptomycin reports. Statistically significant rhabdomyolysis RORs (95% CI) for antibiotics were (in descending order):

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Ivyspringmentioning

confidence: 99%

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Teng¹,

Baus²,

Wilson³

et al. 2019

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Trimethoprim-sulfamethoxazole: There have been several reports of trimethoprim-sulfamethoxazole-induced rhabdomyolysis in immunocompromised patients [ 36 – 39 ], but it seems to be very rare in the immunocompetent patients. To our knowledge, only two cases of trimethoprim-sulfamethoxazole-induced rhabdomyolysis have been reported in immunocompetent patients [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis in a Patient with Severe Hypothyroidism

et al. 2017

View full text Add to dashboard Cite

Patient: Female, 52Final Diagnosis: Hypothyroidism induced rhabdomyolysisSymptoms: Bilateral leg pain • fatigueMedication: Levothyroxine • Calcitriol • Calcium GluconateClinical Procedure: —Specialty: Endocrinology and MetabolicObjective:Unusual clinical courseBackground:Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with symptomatic hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation. In most patients with hypothyroidism who develop rhabdomyolysis, precipitating factors, such as strenuous exercise or use of lipid-lowering drugs, can be identified.Case Report:We report a case of a 52-year-old Hispanic woman with a history of hypothyroidism, hypertension, and type 2 diabetes mellitus who presented with fatigue, severe generalized weakness, bilateral leg pain, and recurrent falls. She reported poor medication compliance for the preceding month. Initial laboratory testing showed elevated thyroid stimulating hormone (TSH) and creatine kinase (CK) levels, indicating uncontrolled hypothyroidism with associated rhabdomyolysis. Supportive treatment with intravenous fluids and intravenous levothyroxine were initiated and resulted in dramatic clinical improvement.Conclusions:We report a case of rhabdomyolysis, which is a rare but potentially serious complication of hypothyroidism. Screening for hypothyroidism in patients with elevated muscle enzymes should be considered, since an early diagnosis and prompt treatment of hypothyroidism is essential to prevent rhabdomyolysis and its consequences.

show abstract

“…The first case series (Case 1 in Table 1) that is of an immunocompetent patient with SMX-TMP-induced rhabdomyolysis by Ainapurapu and Kanakadandi was very similar to our patient in that they were both females in their early 40's, being treated empirically with SMX-TMP for a suspected UTI and experiences an onset of bilateral leg pain on day 2 of therapy [14]. However, no confounding [A] : empiric treatment for presumed UTI.…”

Section: Discussionmentioning

confidence: 99%

“…Our review of the literature found most of the reported cases being in immunocompromised patients with HIV infection [10] [11] [12], or allogeneic stem cell transplant recipient [11] [13]. To the best of our knowledge, our patient is the third case of SMX-TMP-induced rhabdomyolysis in an immunocompetent patient, and the second of the immunocompetent patient to have multiple attributing factors [14] [15]. Verbal consent was obtained from the patient to discuss her case.…”

Section: Introductionmentioning

confidence: 99%

Sulfamethoxazole-Trimethoprim-Induced Rhabdomyolysis in an Immunocompetent Patient: A Case Report

Moye¹,

Manasen²,

O’Brien³

2017

CRCM

View full text Add to dashboard Cite

Sulfamethoxazole-trimethoprim (TMP-SMX)-induced rhabdomyolysis is a rare complication of a commonly used antibiotic. This is a case report of a 43-year old immunocompetent African American woman with a history of depression and chronic alcohol consumption who presented to the emergency department (ED) with worsening bilateral leg pain. Before presentation, the patient was prescribed a twice daily dose of TMP-SMX for a urinary tract infection. The patient reported the development of intensifying leg pain after taking five doses of TMP-SMX. On presentation to the ED she was hemodynamically stable, afebrile, and leg pain intensity 10 out of 10. The patient admitted to daily alcohol consumption and taking vortioxetine 10 mg per day for treatment of depression. Initial labs drawn in the ED showed an elevated creatine kinase (CK) of 26,231 U/L and a normal serum creatinine (SCr) of 1 mg/dL. Through patient history and laboratory tests, common causes of rhabdomyolysis were ruled out. Treatment was initiated with IV fluids plus thiamine and folic acid supplementation, TMP-SMX was discontinued, and vortioxetine 10 mg per day was continued until hospital day five. The patient began to show improvement in lower extremity pain and tenderness and was discharged on hospital day eight with minimal residual leg pain and a CK of 2809 U/L. This case report presents only the third incidence of an immunocompetent patient developing TMP-SMX-induced rhabdomyolysis. This case highlights an opportunity for a pharmacist's intervention and the need for future research to determine risk factors of TMP-SMX-induced rhabdomyolysis in immunocompetent patients.

show abstract

Trimethoprim-Sulfamethoxazole Induced Rhabdomyolysis

Cited by 8 publications

References 5 publications

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)

Rhabdomyolysis in a Patient with Severe Hypothyroidism

Sulfamethoxazole-Trimethoprim-Induced Rhabdomyolysis in an Immunocompetent Patient: A Case Report

Contact Info

Product

Resources

About