Trimethoprim/sulphadiazine compared with penicillin V in the treatment of streptococcal throat infections

Hoskins, T. W.; Bernstein, L. S.

doi:10.1093/jac/8.6.495

Cited by 11 publications

(12 citation statements)

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“…103 Severalantimicrobialagentsare moreeffectiveandreliableforthetreatment of skin, soft tissue, and other staphylococcal infections.…”

Section: Skin-associated Infectionsmentioning

confidence: 99%

“…In a surveillance 102 of international strains, most methicillin-resistant coagulase-negative staphylococcal isolates were resistant to trimethoprim-sulfamethoxazole.Streptococcus pyogenes is variably susceptible. 103 Severalantimicrobialagentsare moreeffectiveandreliableforthetreatment of skin, soft tissue, and other staphylococcal infections.…”

Section: Skin-associated Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Trimethoprim-Sulfamethoxazole Revisited

Masters¹,

O’Bryan²,

Zurlo³

et al. 2003

Arch Intern Med

313

225

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During the past 3 decades, the combination of trimethoprim and sulfamethoxazole has occupied a central role in the treatment of various commonly encountered infections and has also been particularly useful for several specific clinical conditions. However, changing resistance patterns and the introduction of newer broad-spectrum antibiotics have led to the need to carefully redefine the appropriate use of this agent in clinical practice. While trimethoprim-sulfamethoxazole's traditional role as empirical therapy for several infections has been modified by increasing resistance, it remains a highly useful alternative to the new generation of expanded-spectrum agents if resistance patterns and other clinical variables are carefully considered. It also seems to have an increasing role as a cost-effective pathogen-directed therapy with the potential to decrease or delay development of resistance to newer antibiotics used for empirical treatment. In addition, trimethoprim-sulfamethoxazole continues to be the drug of choice for several clinical indications.

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“…103 Severalantimicrobialagentsare moreeffectiveandreliableforthetreatment of skin, soft tissue, and other staphylococcal infections.…”

Section: Skin-associated Infectionsmentioning

confidence: 99%

Section: Skin-associated Infectionsmentioning

confidence: 99%

Trimethoprim-Sulfamethoxazole Revisited

Masters¹,

O’Bryan²,

Zurlo³

et al. 2003

Arch Intern Med

313

225

View full text Add to dashboard Cite

show abstract

“…Two studies (33,51) have reported S. pyogenes uniformly resistant to SXT, but this was prior to thymidine content standardization in Mueller-Hinton agar (MHA) and was on agar containing sheep blood. There have also been reported clinical failures in the use of this agent in eradicating S. pyogenes from nasopharyngeal carriage (30). However, other centers have demonstrated full in vitro susceptibility of S. pyogenes to SXT (14,22,36,54).…”

mentioning

confidence: 99%

Is Streptococcus pyogenes Resistant or Susceptible to Trimethoprim-Sulfamethoxazole?

et al. 2012

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“…Ten studies investigated macrolides [28,31,39,42,45,46,48,53,59,67], three clindamycin [39,45,58] and two co-trimoxazole [40,60] with a wide range of dosing regimens (Supplementary Appendix D). Only one study reported on throat cultures taken at 24 hours following initiation of treatment with a macrolide; 6/15 (40%) remained culture positive [28].…”

Section: Resultsmentioning

confidence: 99%

“…Five studies included individuals with scarlet fever, but none provided disaggregated results for this sub-group [35,37,41,45,56]. Three studies included individuals with asymptomatic carriage, [47,60,64] but only Hoskins et al reported distinct results for this sub-group. This was a small paediatric study in which throat cultures were repeated 3-4 days after starting co-trimoxazole, at which point 4/13 (30.8%) children remained culture positive.…”

Section: Resultsmentioning

confidence: 99%

Time to negative throat culture following initiation of antibiotics for pharyngeal group AStreptococcus: a systematic review and meta-analysis to inform public health control measures

McGuire¹,

Li²,

Collin³

et al. 2022

Preprint

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Background: Public health guidance recommending isolation of individuals with group A streptococcal (GAS) infection or carriage for 12-24 hours from antibiotic initiation to prevent onward transmission requires a strong evidence-base. Methods: We conducted a systematic review (PROSPERO CRD42021290364) and meta-analysis to estimate the pooled proportion of individuals who remain GAS culture-positive at set intervals after initiation of antibiotics. We searched Ovid MEDLINE (1946-), EMBASE (1974-) and the Cochrane library. We included interventional or observational studies with ten or more participants reporting rates of GAS throat culture during antibiotics for culture confirmed GAS pharyngitis, scarlet fever, and asymptomatic pharyngeal GAS carriage. We did not apply age, language, or geographical restrictions. Findings: Of 5,058 unique records identified, 43 were included; 37 (86%) randomised controlled studies, three (7%) non-randomised controlled trials and three (7%) before-and-after studies. The proportion of individuals who remained culture-positive at day 1, day 2, and day 3-9 were 6.9% (95% CI 2.7-16.8%), 5.4% (95% CI 2.1-13.3%) and 2.6% (95% CI 1.6-4.2%). For penicillins and cephalosporins, day 1 positivity was 6.5% (95% CI 2.5-16.1%) and 1.6% (95% CI 0.04-42.9%) respectively. Overall, for 9.1% (95% CI 7.3-11.3), throat swabs collected after completion of therapy were GAS culture-positive. Interpretation: Our review provides evidence that antibiotics for pharyngeal GAS achieve a high rate of culture conversion within 24 hours but highlights the need for further research given the methodological limitations of published studies and imprecision of pooled estimates. Further evidence is needed for non-beta-lactam antibiotics and for asymptomatic individuals.

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Trimethoprim/sulphadiazine compared with penicillin V in the treatment of streptococcal throat infections

Cited by 11 publications

References 0 publications

Trimethoprim-Sulfamethoxazole Revisited

Trimethoprim-Sulfamethoxazole Revisited

Is Streptococcus pyogenes Resistant or Susceptible to Trimethoprim-Sulfamethoxazole?

Time to negative throat culture following initiation of antibiotics for pharyngeal group AStreptococcus: a systematic review and meta-analysis to inform public health control measures

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