Trimethoprim-sulphamethoxazole in enteric fevers.

Typhoid fever is an infectious disease with multisystem involvement and is commonly seen in the tropics. Twelve patients with acute typhoid fever were successfully treated with a fixed dose combination of pivmecillinam and pivampicillin. The treatment results were compared to those obtained from the treatment of ten other patients with co-trimoxazole, which is the routine treatment of our Department. The two forms of treatment appeared to be equally effective, suggesting that the combination mecillinam/ampicillin may represent a valuable alternative to the antityphoidal drugs currently available. Eleven patients were infected with strains resistant in vitro to either ampicillin, chloramphenicol, or both. All clinical isolates were sensitive to co-trimoxazole and to the combination of mecillinam and ampicillin. MIC values for the combination ranged from 0.16 to 2.5 mg/l. No side-effects were recorded.

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The combination of pivmecillinam and pivampicillin compared to co-trimoxazole in the treatment of enteric fever

Tanphaichitra

Bussayanond

Christensen

1982

Infection

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Prospective randomized comparative trial of pefloxacin versus cotrimoxazole in the treatment of typhoid fever in adults

Hajji

Mdaghri

Benbachir

et al. 1988

Eur. J. Clin. Microbiol. Infect. Dis.

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Pefloxacin, which has been shown to have a high in vitro activity against Salmonella spp., was compared to cotrimoxazole in the treatment of typhoid fever in adults. In a prospective, randomized trial, 42 patients with bacteriologically documented typhoid fever received either 400 mg pefloxacin b.i.d. or 160/800 mg cotrimoxazole b.i.d. Duration of treatment was 14 days in both groups. All patients were cured without experiencing a relapse or becoming a salmonella carrier. Apyrexia and resolution of digestive and neurological symptoms were obtained in a significantly shorter time with pefloxacin than with cotrimoxazole. Pefloxacin was well tolerated and more effective than cotrimoxazole in the treatment of typhoid fever.

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Overview. Trimethoprim-Sulfamethoxazole: An Assessment of More Than 12 Years of Use

Salter¹

1982

Clinical Infectious Diseases

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Trimethoprim-sulphamethoxazole in enteric fevers.

Cited by 14 publications

References 6 publications

The combination of pivmecillinam and pivampicillin compared to co-trimoxazole in the treatment of enteric fever

The combination of pivmecillinam and pivampicillin compared to co-trimoxazole in the treatment of enteric fever

Prospective randomized comparative trial of pefloxacin versus cotrimoxazole in the treatment of typhoid fever in adults

Overview. Trimethoprim-Sulfamethoxazole: An Assessment of More Than 12 Years of Use

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