Trimethylaluminium

Drissi-Amraoui, Sammy

doi:10.1055/s-0034-1380539

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that 2a can be cyclized by base catalysis, or by using common peptide coupling reagents (e.g., EDCI, HATU) upon saponification of the ester group. However, we opted for a trimethylaluminum-mediated amidation reaction [4,39] to give rise to 8-benzyl-7-hydroindolo [2,3-d][1]benzazepin-6(5H)-one (3a). This procedure delivered analytically pure 3a in 80% yield as also confirmed by SC-XRD (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction

Kuznetcova¹,

Bacher²,

Vegh³

et al. 2022

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

Paullone isomers are known as inhibitors of tubulin polymerase and cyclin dependent kinases (Cdks), which are potential targets for cancer chemotherapy. Herein we report an efficient and clean pathway to the fourth isomer, which remained elusive so far, namely 7,8-dihydroindolo[2,3-d][1]benzazepin-6(5H)-one. Moreover, we demonstrate the generality of our pathway by synthesizing two closely related analogues, one containing a bromo substituent and the other one incorporating an 8-membered instead of a 7-membered ring. The key transformation in this four-step synthesis, with an overall yield of 29%, is the Fischer indole reaction of 2-nitrophenylacetyl acetoacetate with 1-benzyl-1-phenylhydrazine in acetic acid that delivers methyl 2-(1-benzyl-3-(2-nitrophenyl)-1H-indol-2-yl)acetate in 55% yield.

show abstract

Section: Resultsmentioning

confidence: 99%

Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction

Kuznetcova¹,

Bacher²,

Vegh³

et al. 2022

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

show abstract

“…It typically involves the reaction of elemental aluminum and chloroform to produce dimethylaluminumchloride which is further converted to TMA in a melt by a reaction with sodium. The TMA is distilled from the reaction mixture afterward. − However, for the deposition of material systems other than Al 2 O 3 , ZnO, or HfO 2 by ALD, more complicated chemistries and thus synthetic approaches are normally needed to obtain the desired physicochemical properties of an ALD precursor. , For example, when considering the formation of metallic Ag layers, small molecules such as AgCl or Ag(CH 3 ) cannot be employed for a well-functioning ALD process as they are either not volatile or highly unstable, respectively . Thus, the pertinent design of ligands increasing volatility and thermal stability needs to be considered, which arguably renders the overall environmental impact of the synthesis and consequently whole ALD process chain more challenging.…”

Section: Overview and Discussionmentioning

confidence: 99%

Assessing the Environmental Impact of Atomic Layer Deposition (ALD) Processes and Pathways to Lower It

et al. 2023

View full text Add to dashboard Cite

Due to concerns on resources depletion, climate change, and overall pollution, the quest toward more sustainable processes is becoming crucial. Atomic layer deposition (ALD) is a versatile technology, allowing for the precise coating of challenging substrates with a nanometer control over thickness. Due to its unique ability to nanoengineer interfaces and surfaces, ALD is widely used in many applications. Although the ALD technique offers the potential to tackle environmental challenges, in particular, considerations regarding the sustainability of renewable energy devices urge for greater efficiency and lower carbon footprint. Indeed, the process itself has currently a consequential impact on the environment, which should ideally be reduced as the technique is implemented in a wider range of products and applications. This paper reviews the studies carried out on the assessment of the environmental impact of ALD and summarizes the main results reported in the literature. Next, the principles of green chemistry are discussed, considering the specificities of the ALD process. This work also suggests future pathways to reduce the ALD environmental impact; in particular, the optimization of the reactor and processing parameters, the use of high throughput processes such as spatial ALD (SALD), and the chemical design of greener precursors are proposed as efficient routes to improve ALD sustainability.

show abstract

Tma

Rocoby¹

2020

Catalysis From a to Z

View full text Add to dashboard Cite

Trimethylaluminium

Cited by 4 publications

References 8 publications

Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction

Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction

Assessing the Environmental Impact of Atomic Layer Deposition (ALD) Processes and Pathways to Lower It

Tma

Contact Info

Product

Resources

About