Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling
Yikui Hu,
Yujie Liu,
Hua Wang
et al.
Abstract:Introduction Post-stroke depression (PSD) is one of the common complications after stroke. Trimethylamine-N oxide (TMAO) has been reported to exacerbate brain injury after ischemic stroke, and its expression is positively related to the severity of depressive symptoms. This study was performed to investigate the role and mechanism of TMAO in PSD. Methods The classical stroke model was combined with spatial constraint stress to establish a PSD mouse model, and the effect of TMAO on the depression-like behavior … Show more
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