Trimethylene Oxide

Henegar, Kevin E.; Muchnij, Jill A.; Maleczka, Robert E.

doi:10.1002/047084289x.rt273.pub2

Cited by 1 publication

(1 citation statement)

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“…40 For the first time, our group showed that interstitial fibrosis accumulates in obese WAT 40 properties, increased proliferation and diminished differentiation (see Figure 4). [46][47][48] The phenotypic modification of pre-adipocytes appears to be reversible in vitro when the inflammation stimulus is suppressed Pathophysiological Aspects of Human Obesity -What We Know in 2010 90,91 Macrophages modify the biology of adipocytes and pre-adipocytes via the local production of adipokines. Tumour necrosis factor alpha (TNF-α) has been proposed to mediate some effects.…”

Section: Disease Of the White Adipose Organ -Inflammation Metabolic mentioning

confidence: 99%

Pathophysiological Aspects of Human Obesity – What We Know in 2010

Clément¹,

Basdevant²

2010

European Endocrinology

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Obesity, a disease of both developed and developing countries, is spreading at an epidemic pace. According to the World Health Organization (WHO), obesity is defined as an increase or abnormal accumulation of body fat mass to the extent that an individual's health will be negatively affected. Overweight (i.e. body mass index [BMI] >25kg/m 2 ) is considered to be a significant risk factor for the development of many chronic diseases. Environmental, behavioural, genetic and biological factors interact to cause obesity, which can be viewed as a set of phenotypes that evolve over time in stages that need to be precisely measured. This article provides a clinical viewpoint on some biological processes that may explain some of the stages in the development of human obesity, its chronic maintenance and the occurrence of complications, with a focus on brain structures, genetics, the profound alterations in adipose tissue biology and the recent revival in thinking in terms of brown adipose tissue.

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