Trimethylsilyl-based reagents

Activation of Si–Si Bonds for Copper(I)‐Catalyzed Conjugate Silylation

“…[1] Among the different methods, the metal-mediated conjugate addition of nucleophilic silicon is particularly attractive, because it leads to the formation of functionalized –-silyl carbonyl compounds. [2] Although the use of commercially available disilanes has been studied, the generation of nucleophilic silicon by activation of a Si–Si bond [3] from disilanes is limited to Pd- [4] and Cu-catalyzed [5] conjugate silylation of enones and enals.…”

Copper-catalyzed silylation of p-quinone methides: new entry to dibenzylic silanes

“…Silicon-containing molecules are valuable synthetic intermediates which can be converted into useful compounds through a number of transformations. 4 Recently, copper-catalyzed silylation reactions have emerged as a powerful tool for C–Si bond formation. 5 We envisioned that insertion of the exocyclic double bond into the Cu–Si bond followed by aromatization would afford non-symmetric benzylic silanes.…”

Highly Selective Hydroxylation and Alkoxylation of Silanes: One-Pot Silane Oxidation and Reduction of Aldehydes/Ketones

“…Orgnosilanols are fundamentally important skeletons in many natural products, bioactive compounds, and functional materials − (i.e., for the production of silicon-based polymers, functional groups of drugs, efficient donors for metal-catalyzed coupling reactions, and organocatalysts). Due to the widespread application of organosilanols in the material and pharmaceutical industry, extensive efforts have been devoted to the development of efficient protocols for the preparation of organosilanols. − …”