TRIP6: An adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity

Abstract

Thyroid hormone receptor interacting protein 6 (TRIP6), also known as zyxin-related protein-1 (ZRP-1), is an adaptor protein that belongs to the zyxin family of LIM proteins. TRIP6 is primarily localized in the cytosol or focal adhesion plaques, and may associate with the actin cytoskeleton. Additionally, it is capable of shuttling to the nucleus to serve as a transcriptional coregulator. Structural and functional analyses have revealed that through multidomain-mediated protein-protein interactions, TRIP6 serves as a platform for the recruitment of a wide variety of signaling molecules involved in diverse cellular responses, such as actin cytoskeletal reorganization, cell adhesion and migration, antiapoptotic signaling, osteoclast sealing zone formation and transcriptional control. Although the physiological functions of TRIP6 remain largely unknown, it has been implicated in cancer progression and telomere protection. Together, these studies suggest that TRIP6 plays multifunctional roles in different cellular responses, and thus may represent a novel target for therapeutic intervention.

TRIP6 Regulates p27KIP1 To Promote Tumorigenesis

“…As such, it is not surprising that these LIM proteins, in particular TRIP6 and LPP, share some of the same binding partners (1). Indeed, the in vitro GST pulldown assays showed that LPP, but not zyxin, also bound to both p27 KIP1 and AKT1 directly albeit with a lower affinity than TRIP6 (Fig.…”

“…hyroid hormone receptor-interacting protein 6 (TRIP6) is a zyxin-related adaptor protein and focal adhesion molecule (1). Through its three LIM domains, PDZ-binding motif, Crk SH2-binding motif, and several putative SH3-binding domains, TRIP6 associates with a variety of molecules from the cell surface to the nucleus to regulate actin reorganization, focal adhesion assembly/disassembly, cell migration/invasion, antiapoptotic signaling, and transcriptional control.…”

Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival

“…Thyroid hormone receptor-interacting protein 6 (TRIP6) is a zyxin-related adaptor protein and focal adhesion molecule (28). TRIP6 associates with a variety of molecules from the cell surface to the nucleus, regulates actin reorganization, focal adhesion assembly/disassembly, cell migration/invasion, antiapoptotic signaling, and transcriptional control.…”

Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27Kip1 expression in non-Hodgkin’s lymphoma

“…Thyroid hormone receptor-interacting protein 6 (TRIP6), a LIM proteins family member, is an adaptor protein that mediates many cell responses, such as actin cytoskeletal reorganization and cell adhesion [7]. Accumulating data suggest that TRIP6 can exert a critical role in cancer progression.…”