Tripartite motif containing 28 (TRIM28) promotes the growth and migration of endometrial carcinoma cells by regulating the 
AKT/mTOR signaling pathway

Chen, Yue; Cheng, Haiyan; Long, Heming

doi:10.4149/gpb_2021009

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…These cell proliferation could be abrogated by the specific mTOR inhibitor everolimus ( 24 ). Similarly, TRIM28 can promote endometrial cancer cell growth and migration by activating AKT/mTOR signaling pathway ( 25 ). TRIM28 can also play a role in tumor cell proliferation as a direct target of microRNAs.…”

Section: Role Of Trim28 In the Cancer Cell Cycle And Proliferationmentioning

confidence: 99%

The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

et al. 2023

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Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression. More and more studies have shown that TRIM28 plays a vital role in tumor genesis and progression. Here, we reviewed the role of TRIM28 in tumor proliferation, migration, invasion and cell death. Moreover, we also summarized the important role of TRIM28 in tumor stemness sustainability and immune regulation. Because of the importance of TRIM28 in tumors, TIRM28 may be a candidate target for anti-tumor therapy and play an important role in tumor diagnosis and treatment in the future.

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Section: Role Of Trim28 In the Cancer Cell Cycle And Proliferationmentioning

confidence: 99%

The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

et al. 2023

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“…VCAM1 [1413], PTPRD (protein tyrosine phosphatase receptor type D) [1426] and hsa-mir-17-5p [1689] are associated with prognosis in patients with gestational diabetes mellitus. IGF2BP1 [453], DAPK1 [183], PTPRD (protein tyrosine phosphatase receptor type D) [412], TCF3 [1690], SMARCA4 [1691] and TRIM28 [1692] biomarkers are vital for endometrial cancer. Research have shown that PTPRD (protein tyrosine phosphatase receptor type D) [656], PDGFB (platelet derived growth factor subunit B) [642], DAPK1 [751], hsa-mir-4432 [1693], SMARCA4 [1694] and TRIM28 [1695] participates in hypertension.…”

Section: Discussionmentioning

confidence: 99%

Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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Endometriosis is a common cause of endometrial-type mucosa outside the uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain with intercourse and infertility. However, the early diagnosis of endometriosis is still restricted. The purpose of this investigation is to identify and validate the key biomarkers of endometriosis. Next generation sequencing (NGS) dataset GSE243039 was obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) between endometriosis and normal control samples were identified. After screening of DEGs, gene ontology (GO) and REACTOME pathway enrichment analyses were performed. Furthermore, a protein-protein interaction (PPI) network was constructed and modules were analysed using the Human Integrated Protein-Protein Interaction rEference (HIPIE) database and Cytoscape software, and hub genes were identified. Subsequantely, a network between miRNAs and hub genes, and network between TFss and hub genes were constructed using the miRNet and NetworkAnalyst tool, and possible key miRNAs and TFs were predicted. Finally, receiver operating characteristic curve (ROC) analysis was used to validate the hub genes. A total of 958 DEGs, including 479 up regulated genes and 479 down regulated genes, were screened between endometriosis and normal control samples. GO and REACTOME pathway enrichment analyses of the 958 DEGs showed that they were mainly involved in multicellular organismal process, developmental process, signaling by GPCR and muscle contraction. Further analysis of the PPI network and modules identified 10 hub genes, including VCAM1, SNCA, PRKCB, ADRB2, FOXQ1, MDFI, ACTBL2, PRKD1, DAPK1 and ACTC1. Possible target miRNAs, including hsa-mir-3143 and hsa-mir-2110, and target TFs, including TCF3 and CLOCK, were predicted by constructing a miRNA-hub gene regulatory network and TF-hub gene regulatory network. This investigation used bioinformatics techniques to explore the potential and novel biomarkers. These biomarkers might provide new ideas and methods for the early diagnosis, treatment, and monitoring of endometriosis.

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Multifaceted role of TRIM28 in health and disease

Maghsoudloo,

Mokhtari,

Jamali

et al. 2024

MedComm

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The TRIM (tripartite motif) family, with TRIM28 as a key member, plays a vital role in regulating health and disease. TRIM28 contains various functional domains essential for transcriptional regulation, primarily through its interaction with KRAB‐ZNF proteins, which influence chromatin remodeling and gene expression. Despite extensive research, the precise mechanisms by which TRIM28 impacts health and disease remain elusive. This review delves into TRIM28’s multifaceted roles in maintaining health, contributing to a variety of diseases, and influencing cancer progression. In cancers, TRIM28 exhibits a dual nature, functioning as both a tumor promoter and suppressor depending on the cellular context and cancer type. The review also explores its critical involvement in processes such as DNA repair, cell cycle regulation, epithelial‐to‐mesenchymal transition, and the maintenance of stem cell properties. By uncovering TRIM28’s complex roles across different cancers and other diseases, this review underscores its potential as a therapeutic target. The significance of TRIM28 as a versatile regulator opens the door to innovative therapeutic strategies, particularly in cancer treatment and the management of other diseases. Ongoing research into TRIM28 may yield key insights into disease progression and novel treatment options.

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Tripartite motif containing 28 (TRIM28) promotes the growth and migration of endometrial carcinoma cells by regulating the AKT/mTOR signaling pathway

Cited by 7 publications

References 19 publications

The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

Multifaceted role of TRIM28 in health and disease

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