Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease

Kraskovskaya, Nina; Kukanova, E. O.; Linkova, N. S.; Попугаева, Елена; Khavinson, V. Kh.

doi:10.1007/s10517-017-3847-2

Cited by 13 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, few of them focused on the effects on target tissues, and the amount of active ingredients reached target tissues simultaneously. For instance, in the research of neuroprotective peptides, the effects of combination treatment on nerve cells have been extensively studied, but the distribution of peptides in the brain is always neglected. , In this study, we found that TP was able to not only enhance the protective effect of DWMH-derived peptides on oxidatively damaged nerve cells but also promote the accumulation of peptides in brain tissue. The enhancement of TP on memory impairment reversal effects of DWMH in vivo is attributed to the above two aspects.…”

Section: Discussionmentioning

confidence: 67%

Coadministration with Tea Polyphenols Enhances the Neuroprotective Effect of Defatted Walnut Meal Hydrolysate against Scopolamine-Induced Learning and Memory Deficits in Mice

Sheng

Yang

Liu

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

The present study aimed to investigate the combined effects of defatted walnut meal hydrolysate (DWMH) and tea polyphenols (TP) on learning improvement and to explain mechanistically why the combined treatments were more effective than either subject alone. In the step-down avoidance test and the Morris water maze test, codelivery of DWMH and TP was more effective than either individual supplement in reversing memory impairment in scopolamine-treated mice. Mixing with TP significantly facilitated the protective effects of DWMH or DWMH-derived peptides (cationic peptide P1 and anionic peptide P2) on H2O2-injured SH-SY5Y cells. Although combination treatment with TP and DWMH did not significantly alter systemic exposure to P1 or P2 in rats, it significantly increased the accumulation of the two peptides in the mouse brain. In addition, TP significantly improved cellular uptake of P1 and P2 by brain capillary endothelial cells, indicating that TP enhanced the blood–brain barrier permeation of DWMH-derived peptides. The proposed explanation for the advantage of combined treatment with TP and DWMH in reversing memory impairment was that TP enhanced both the protective effects of DWMH on nerve cells and the accumulation of DWMH in the brain. Our study can aid efforts to develop products and investigate the effects of nutrient combinations on brain disorders.

show abstract

Section: Discussionmentioning

confidence: 67%

Coadministration with Tea Polyphenols Enhances the Neuroprotective Effect of Defatted Walnut Meal Hydrolysate against Scopolamine-Induced Learning and Memory Deficits in Mice

Sheng

Yang

Liu

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Increased the amount of mushroom spines in hippocampal neurons in Alzheimer disease culture mouse model by 20%. 25 5. Stimulated serotonin expression in neuronal cell culture.…”

Section: Mtt Assaymentioning

confidence: 99%

Effect of short peptides on neuronal differentiation of stem cells

Caputi

Trubiani

Sinjari

et al. 2019

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

It has been demonstrated that short peptides play an important role in the transmission of biological information, modulation of transcription, and restoring genetically conditioned alterations occurring with age. Peptidergic regulation of homeostasis occupies an important place in physiological processes, which lead to the aging of cells, tissues, and organs, consisting in the involution of major regulatory systems-the nervous, the endocrine, and the immune. The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis. Growth-Associated Protein 43 (GAP43), which implements neurotransmission mechanisms and neuroplasticity, demonstrated an increased expression in hPDLSCs cultured with a compound of all studied peptides and with KED alone. The peptide compound and KED, increase the expression of Nestin (neurofilament protein), expressed in early neuronal precursors in hPDLSCs cultures. Thus, the compound of peptides AEDG, KE, AED, and KED could promote the neuronal differentiation of hPDLSCs and be a promising tool for the study of peptides as a modulator of neurogenesis in neurodegenerative diseases studied in animal models.

show abstract

“…It is significant that the KED vasoprotective peptide [60], which has a neuroprotective effect in models of Alzheimer's disease in mice in vitro and in vivo [61,62], regulated the mRNA involved in expression of the cell senescence and apoptosis genes (p16, p21), of neurogenesis (NES, GAP43), and of other genes involved in the pathogenesis of Alzheimer's disease (SUMO1, APOE, IGF1) [22]. It should be noted that as such short peptides can regulate the expression of genes responsible for functions of the cell populations of the brain, this indicates promising prospects for using short peptides for neuroprotection.…”

Section: Peptide Regulation Of the Functional Activity Of Cellsmentioning

confidence: 99%

Peptide Regulation of Gene Expression: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synthesis in plants, microorganisms, insects, birds, rodents, primates, and humans. Short peptides, consisting of 2–7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA–peptide interactions, including sequence recognition in gene promoters, are important for template-directed synthetic reactions, replication, transcription, and reparation. Peptides can regulate the status of DNA methylation, which is an epigenetic mechanism for the activation or repression of genes in both the normal condition, as well as in cases of pathology and senescence. In this context, one can assume that short peptides were evolutionarily among the first signaling molecules that regulated the reactions of template-directed syntheses. This situation enhances the prospects of developing effective and safe immunoregulatory, neuroprotective, antimicrobial, antiviral, and other drugs based on short peptides.

show abstract

Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease

Cited by 13 publications

References 10 publications

Coadministration with Tea Polyphenols Enhances the Neuroprotective Effect of Defatted Walnut Meal Hydrolysate against Scopolamine-Induced Learning and Memory Deficits in Mice

Coadministration with Tea Polyphenols Enhances the Neuroprotective Effect of Defatted Walnut Meal Hydrolysate against Scopolamine-Induced Learning and Memory Deficits in Mice

Effect of short peptides on neuronal differentiation of stem cells

Peptide Regulation of Gene Expression: A Systematic Review

Contact Info

Product

Resources

About