Triphenylamine flanked boron difluoride formazanate for NIR-II fluorescence imaging-guided photothermal therapy

Li, Hui; Dai, Hanming; Mei, Anqing; Ruan, Xiaohong; Wang, Weili; Yang, Dongliang; Wang, Wenjun; Zhang, Qi; Dong, Xiaochen; Shao, Jinjun

doi:10.1016/j.dyepig.2022.110478

Cited by 8 publications

(4 citation statements)

References 51 publications

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“…113−116 Compared with inorganic therapeutic agents, organic molecules exhibit definite chemical structures and superior biocompatibility, demonstrating the powerful prospects in cancer therapeutics. 117,118 Among them, the BBT-based small molecular tumor phototheranostics platforms have attracted extensive research attention in the past few years.…”

Section: Dual-mode Imagingmentioning

confidence: 99%

“…Phototherapy is a light-induced therapy that utilizes photosensitizers to kill tumor cells. It encompasses photothermal therapy (PTT) and photodynamic therapy (PDT) as primary modalities, which has garnered significant scholarly exploration owing to its noninvasiveness, negligible impact on healthy tissues, and effective tumor-suppressing capability. − Compared with inorganic therapeutic agents, organic molecules exhibit definite chemical structures and superior biocompatibility, demonstrating the powerful prospects in cancer therapeutics. , Among them, the BBT-based small molecular tumor phototheranostics platforms have attracted extensive research attention in the past few years.…”

Section: Bbt-based Nir-ii Fluorophores For Phototheranosticsmentioning

confidence: 99%

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Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Wang,

Li,

Wang

et al. 2024

ACS Nano

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Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation in cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), with high electron affinity, is widely utilized as the electron acceptor in constructing donor−acceptor−donor (D-A-D) structured fluorophores with intensive near-infrared (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based NIR-II dyes have been employed in tumor phototheranostics due to their exceptional structure tunability, biocompatibility, and photophysical properties. This review systematically overviews the research progress of BBT-based small molecular NIR-II dyes and focuses on molecule design and bioapplications. First, the molecular engineering strategies to fine-tune the photophysical properties in constructing the high-performance BBT-based NIR-II fluorophores are discussed in detail. Then, their biological applications in optical imaging and phototherapy are highlighted. Finally, the current challenges and future prospects of BBT-based NIR-II fluorescent dyes are also summarized. This review is believed to significantly promote the further progress of BBT-derived NIR-II fluorophores for cancer phototheranostics.

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Section: Dual-mode Imagingmentioning

confidence: 99%

Section: Bbt-based Nir-ii Fluorophores For Phototheranosticsmentioning

confidence: 99%

Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Wang,

Li,

Wang

et al. 2024

ACS Nano

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“…Therefore, researchers adopted a variety of strategies to enhance enzyme activity and antibacterial activities of peroxidase mimics. 13,[53][54][55][56][57] Wang et al reported a nanoreactor (GOx-CaPCuPt) with a core-shell structure, the core of which is Cu 2 O/Pt nanozyme, which not only has POD-like activity but also has good photothermal properties. 8 When the nanoreactor enters the traumatic environment, the Ca 3 (PO 4 ) 2 (CaP) layer will be degraded, GOx catalyzes glucose decomposition to further reduce the pH value of the wound, and then Cu 2 O/Pt produces a large amount of ROS through the Fenton reaction for the eradication of bacteria; the photothermal properties of Cu 2 O/Pt nanozymes were used to enhance chemodynamic therapy (CDT) (Fig.…”

Section: (C) and (D))mentioning

confidence: 99%

Recent progress in nanozymes for the treatment of diabetic wounds

Jiang

et al. 2023

J. Mater. Chem. B

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“…Numerous studies have demonstrated that photothermal therapy exhibits remarkable efficacy in cancer treatment [ 17 , 18 , 19 ]. Compared to the traditional treatments like radiotherapy and chemotherapy, PTT possesses the superiorities of non-invasiveness, remote controllability, minimal side effects, and insignificant drug resistance [ 20 , 21 , 22 ]. To improve the efficiency of PTT, tremendous efforts have been made on the construction of high-performance PTAs.…”

Section: Introductionmentioning

confidence: 99%

High-Performance Hybrid Phototheranostics for NIR-IIb Fluorescence Imaging and NIR-II-Excitable Photothermal Therapy

et al. 2023

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Photothermal therapy operated in the second near-infrared (NIR-II, 1000–1700 nm) window and fluorescence imaging in the NIR-IIb (1500–1700 nm) region have become the most promising techniques in phototheranostics. Their combination enables simultaneous high-resolution optical imaging and deep-penetrating phototherapy, which is essential for high-performance phototheranostics. Herein, carboxyl-functionalized small organic photothermal molecules (Se-TC) and multi-layered NIR-IIb emissive rare-earth-doped nanoparticles (NaYF4:Yb,Er,Ce@NaYF4:Yb,Nd@NaYF4, RENP) were rationally designed and successfully synthesized. Then, high-performance hybrid phototheranostic nanoagents (Se-TC@RENP@F) were easily constructed through the coordination between Se-TC and RENP and followed by subsequent F127 encapsulation. The carboxyl groups of Se-TC can offer strong binding affinity towards rare-earth-doped nanoparticles, which help improving the stability of Se-TC@RENP@F. The multilayered structure of RENP largely enhance the NIR-IIb emission under 808 nm excitation. The obtained Se-TC@RENP@F exhibited high 1064 nm absorption (extinction coefficient: 24.7 L g−1 cm−1), large photothermal conversion efficiency (PCE, 36.9%), good NIR-IIb emission (peak: 1545 nm), as well as great photostability. Upon 1064 nm laser irradiation, high hyperthermia can be achieved to kill tumor cells efficiently. In addition, based on the excellent NIR-IIb emission of Se-TC@RENP@F, in vivo angiography and tumor detection can be realized. This work provides a distinguished paradigm for NIR-IIb-imaging-guided NIR-II photothermal therapy and establishes an artful strategy for high-performance phototheranostics.

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Triphenylamine flanked boron difluoride formazanate for NIR-II fluorescence imaging-guided photothermal therapy

Cited by 8 publications

References 51 publications

Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Recent progress in nanozymes for the treatment of diabetic wounds

High-Performance Hybrid Phototheranostics for NIR-IIb Fluorescence Imaging and NIR-II-Excitable Photothermal Therapy

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