Triphlorethol-A Improves the Non-Homologous End Joining and Base-Excision Repair Capacity Impaired by Formaldehyde

Zhang, Rui; Kang, Kyoung Ah; Piao, Mei Jing; Kim, Ki Cheon; Lee, Nam Ho; You, Ho Jin; Hyun, Jin Won

doi:10.1080/15287394.2011.567957

Cited by 9 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). Our results are in agreement with other research, that suggests that formaldehyde can induce oxidative stress by increasing the ROS formation [2,9,11,20,25,32]. Formaldehyde generates ROS that induces DNA base modifications and DNA strand breakage contributes to mutagenesis and other pathological processes [32].…”

supporting

confidence: 93%

Lipid Peroxidation in the Heart and Liver of Rainbow Trout (Oncorhynchus Mykiss) Upon Disinfection by Formalin

Tkachenko¹,

Grudniewska²

2018

STBIAS

View full text Add to dashboard Cite

The article highlights the results of scientific research, as well as the practical use of the achievements of scientists of the Institute of Animal Science NAAS in the fields of dairy and beef cattle breeding and genetics, biotechnology, reproduction, maintenance technologies, mechanization, an animal's feeding and nutrition standards development, as well as economical point, feed resources and livestock products quality ensuring and safety. The problems and prospects of scientific research in modern economic and climatic conditions of industry development were discussed in the article. Institute scientists belong the priority theoretical and applied developments, which played a decisive role in the development of high-tech livestock production in the historical aspect, the new breeds and types of dairy and beef cattle creation, the modern system of large-scale breeding introduction, based on domestic competitive technologies of herd reproduction, uniform full-feeding during whole production cycle. The modern developments of the institute team influence to the strategy and methodology formation of competitive high-quality livestock products technological support in different organizational production farms.

show abstract

supporting

confidence: 93%

Lipid Peroxidation in the Heart and Liver of Rainbow Trout (Oncorhynchus Mykiss) Upon Disinfection by Formalin

Tkachenko¹,

Grudniewska²

2018

STBIAS

View full text Add to dashboard Cite

show abstract

“…Cell death may abolish various cellular signaling pathways, including anti-oxidative processes, such as the Nrf2 signaling pathway [ 39 ]. Our results presented here suggest that triphlorethol-A can suppress oxidative stresses and thereby protect cells against noxious stimuli, such as H 2 O 2 , formaldehyde, and ionizing radiation [ 21 , 22 , 24 , 40 , 41 ]. Upon exposure to various stress inducers, Nrf2 is released from Keap1 and translocates into the nucleus [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 97%

“…Triphlorethol-A is a phlorotannin compound derived from the brown alga Ecklonia cava . Our recent study showed that triphlorethol-A increases heme oxygenase-1 activity by elevating the transcriptional activity of Nrf2 [ 21 ], and also ameliorates the effects of formaldehyde on non-homologous end joining and BER capacity [ 22 ]. Furthermore, this compound enhances the activities of the antioxidant system and inhibits cellular damage against ultraviolet B rays, thereby protecting human keratinocytes against ultraviolet B radiation [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1

et al. 2014

View full text Add to dashboard Cite

This study investigated the protective mechanisms of triphlorethol-A, isolated from Ecklonia cava, against oxidative stress-induced DNA base damage, especially 8-oxoguanine (8-oxoG), in Chinese hamster lung fibroblast V79-4 cells. 8-Oxoguanine DNA glycosylase-1 (OGG1) plays an important role in the removal of 8-oxoG during the cellular response to DNA base damage. Triphlorethol-A significantly decreased the levels of 8-oxoG induced by H2O2, and this correlated with increases in OGG1 mRNA and OGG1 protein levels. Furthermore, siOGG1-transfected cell attenuated the protective effect of triphlorethol-A against H2O2 treatment. Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcription factor for OGG1, and Nrf2 combines with small Maf proteins in the nucleus to bind to antioxidant response elements (ARE) in the upstream promoter region of the OGG1 gene. Triphlorethol-A restored the expression of nuclear Nrf2, small Maf protein, and the Nrf2-Maf complex, all of which were reduced by oxidative stress. Furthermore, triphlorethol-A increased Nrf2 binding to ARE sequences and the resulting OGG1 promoter activity, both of which were also reduced by oxidative stress. The levels of the phosphorylated forms of Akt kinase, downstream of phosphatidylinositol 3-kinase (PI3K), and Erk, which are regulators of OGG1, were sharply decreased by oxidative stress, but these decreases were prevented by triphlorethol-A. Specific PI3K, Akt, and Erk inhibitors abolished the cytoprotective effects of triphlorethol-A, suggesting that OGG1 induction by triphlorethol-A involves the PI3K/Akt and Erk pathways. Taken together, these data indicate that by activating the DNA repair system, triphlorethol-A exerts protective effects against DNA base damage induced by oxidative stress.

show abstract

Potential Interventions on Formaldehyde-Induced Neuronal Toxicity

Zhang

2017

Formaldehyde and Cognition

View full text Add to dashboard Cite

Triphlorethol-A Improves the Non-Homologous End Joining and Base-Excision Repair Capacity Impaired by Formaldehyde

Cited by 9 publications

References 41 publications

Lipid Peroxidation in the Heart and Liver of Rainbow Trout (Oncorhynchus Mykiss) Upon Disinfection by Formalin

Lipid Peroxidation in the Heart and Liver of Rainbow Trout (Oncorhynchus Mykiss) Upon Disinfection by Formalin

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1

Potential Interventions on Formaldehyde-Induced Neuronal Toxicity

Contact Info

Product

Resources

About