2024
DOI: 10.26434/chemrxiv-2024-w6pc2
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Triple acquisition mass spectrometry (TRAM) combining targeted and non-targeted metabolomics in a single run

Lisa Panzenboeck,
Harald Schoeny,
Bruno Stelzer
et al.

Abstract: We introduce TRAM, a triple acquisition strategy on high-speed, time-of-flight mass spectrometry for merging non-targeted and targeted metabolomics into one run. TRAM stands for “quasi-simultaneous” acquisition of (1) a full scan MS1, (2) top 30 data-dependent MS2 (DDA), and (3) targeted scheduled MS2 for multiple reaction monitoring (MRM) within measurement cycles of ~ 1 second. TRAM combines the selectivity and sensitivity of state-of-the-art targeted MRM-based methods with the full scope of non-targeted ana… Show more

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