Triple antibiotic paste in root canal therapy

Abstract

The success of the endodontic treatment depends on the microbial suppression in the root canal and periapical region. Endodontic instrumentation alone cannot achieve a sterile condition. With the advent of non-instrumentation endodontic treatment and lesion sterilization and tissue repair, local application of antibiotics has been investigated. Triple antibiotic paste (TAP) containing metronidazole, ciprofloxacin, and minocycline has been reported to be a successful regimen in controlling the root canal pathogen and in managing non-vital young permanent tooth. This paper reviews the existing literature on biocompatibility, efficiency, drawbacks of TAP in endodontic therapy and pulp revascularization.

Revascularization Technique for the Treatment of External Inflammatory Root Resorption: A Report of 3 Cases

“…This paste has an excellent antimicrobial spectrum and possesses the ability to penetrate the dentinal tubules (11)(12)(13). It has been shown to be more effective against bacteria in biofilms than calcium hydroxide (14).…”

“…Thus, the elimination of intracanal infection is a mandatory requirement to the initiation of REPs (17,18). The most common medicament used in REPs is the triantibiotic paste (19), which has been shown to be effective in RCS disinfection (11)(12)(13)(14).…”

A New Era in Treatment of Non - Vital Primary Molars: One Year Follow-up Study

“…Both clinical and radiographic evaluation was done at each follow-up visit. The outcome of success or failure was determined by the following clinical and radiographical criteria [8]:…”

Clinical and Radiographical Evaluation of the Healing of Large Periapical Lesions using Triple Antibiotic Paste, Photo Activated Disinfection and Calcium Hydroxide When used as Root Canal Disinfectant

“…Thus, the search for a better alternative has led to the discoveries of newer antimicrobial agents. The Cariology Research Unit of the Niigata University has developed the concept of 'Lesion sterilization and tissue repair LSTR' therapy (3,4) that employs the use of a combination of antibacterial drugs for disinfection of oral infectious lesions, including dentinal, pulpal, and periradicular lesions. Repair of damaged tissues can be expected if lesions are disinfected (5).…”