Triple combination of heat, drug and radiation using alginate hydrogel co-loaded with gold nanoparticles and cisplatin for locally synergistic cancer therapy

Mirrahimi, Mehri; Beik, Jaber; Mirrahimi, Mehraban; Alamzadeh, Zahra; Teymouri, Samaneh; Mahabadi, Vahid Pirhajati; Eslahi, Neda; Tazehmahalleh, Fatemeh Ebrahimi; Ghaznavi, Habib; Shakeri‐Zadeh, Ali; Moustakis, Christos

doi:10.1016/j.ijbiomac.2020.04.272

Cited by 71 publications

(37 citation statements)

References 48 publications

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“…The inorganic materials with photothermal effects include carbon nanotubes [ 49 , 50 , 51 ], reduced graphene oxide (rGO) [ 52 , 53 ], gold nanoparticles [ 54 , 55 , 56 ], BP [ 57 , 58 ], AuPds [ 31 ], silver [ 59 ], TiO 2 [ 60 ], and platinum nanoparticles [ 61 ]. However, the aggregation of nanoparticles in organisms limits their applications.…”

Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…[ 94 ] The NHs showed excellent mechanical properties, swelling properties, and gel properties. [ 95–99 ] An injectable NIR/pH‐responsive NH was prepared by introducing gold nanorods into a hydrogel network formed by copolymerization of N ‐isopropylacrylamide and poly‐ β ‐cyclodextrin methacrylate macromolecules, which can be used as a long‐acting implant for chemo‐photothermal synergistic therapy of tumors. The in vivo antitumor trials have shown that NHs have the ability of chemothermal synergistic therapy, reducing adverse reactions due to prolonged retention time in the tumor region and effective photothermal effects.…”

Section: Nanomaterials Commonly Used In Nhs and Their Functionsmentioning

confidence: 99%

Injectable Nanocomposite Hydrogels for Cancer Therapy

Zong

Guo

et al. 2021

Macromolecular Bioscience

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Hydrogel is a kind of 3D polymer network with strong swelling ability in water and appropriate mechanical and biological properties, which make it feasible to maintain bioactive substances and has promising applications in the fields of biomaterials, soft machines, and artificial tissues. Unfortunately, traditional hydrogels prepared by chemical crosslinking have poor mechanical properties and limited functions, which limit their further application. In recent years, with the continuous development of nanoparticle research, more and more studies have combined nanoparticles with hydrogels to make up for the shortcomings of traditional hydrogels. In this article, the types and functions of hydrogels and nanomaterials are introduced first, as well as the functions and applications of injectable nanocomposite hydrogels (INHs), then the latest progress of INHs for cancer treatment is reviewed, some existing problems are summarized, and the application prospect of NHs is prospected.

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“…69 The differences in drug loading, also could lead to a different pharmacological The nanoplatform increased tumor heating and damaged tumor cells in vivo and in vitro. 71,72 The use of AuNP for phototherapy can cause hyperthermia, which leads to the apoptosis of cancer cells. Thermal stress also results in the radiosensitization of the cancer site, thus assisting radiotherapy.…”

Section: Advantages Disadvantagesmentioning

confidence: 99%

Active Targeting Gold Nanoparticle for Chemotherapy Drug Delivery: A Review

Gumala¹,

Sutriyo²

2021

Pharm Sci

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Objective Active targeting strategy in chemotherapy drug delivery aims to improve the therapeutic outcomes and minimise the side effects of chemotherapeutics. This review discusses utilising ligands attached to gold nanoparticles (AuNPs) along with several specific ligands attached to AuNPs for active targeting in chemotherapy drug delivery. Key finding Antibodies, peptides, vitamins, DNA, polysaccharides, aptamers, and hormones showed active-targeting abilities as ligands attached to AuNPs. Active-targeting AuNPs enhanced cellular uptake and cytotoxicity in a specific cancer cell in vitro while reducing tumor growth in vivo by improving the photothermal, photodynamic and chemotherapy effects. Active-targeting ligands increased the internalization of AuNPs loaded onto the specific tumour site and minimised the accumulation in the normal site. Conclusion AuNPs with active-targeting ligands such as antibodies, peptides, vitamins, DNA polysaccharides, aptamers, and hormones can improve the therapeutic outcomes of chemotherapeutics and can attenuate the toxicity effect in normal cells. For further research and development, researchers should be addressing AuNP characterization, drug–ligand disposition, active-targeting AuNP quantification, and target-AuNPs pertinence concerning the desired therapeutic outcomes.

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Triple combination of heat, drug and radiation using alginate hydrogel co-loaded with gold nanoparticles and cisplatin for locally synergistic cancer therapy

Cited by 71 publications

References 48 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Injectable Nanocomposite Hydrogels for Cancer Therapy

Active Targeting Gold Nanoparticle for Chemotherapy Drug Delivery: A Review

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