Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature

Abstract

IntroductionThe occurrence of multiple primary cancers is rare. Only a few cases and patient reviews of an association of triple malignancy have been reported.Case presentationWe report here a case of a 78-year-old Moroccan woman presenting initially with a synchronous double malignancy, the first in her cervix and the second in her skin. Our patient was treated with radiation therapy for both tumors and remained in good control for 17 years, when she developed a metastatic disease from a neuroendocrine carcinoma of an unknown primary site.ConclusionsAlthough the association of multiple primary cancers can be considered a rare occurrence, improving survival in cancer patients has made this situation more frequent.

Sero-prevalence of HPV-16 IgG Antibodies and Its Association with Socio Demographic Features of Women in Lokoja, Kogi State, Nigeria

“…Distribution of HPV IgG antibodies based on marital status revealed that those respondents that were divorced and widowed had the highest rate of prevalence. This is observation is similar to the findings of [25,26,27] that reported a higher HPV prevalence among married women, because even though they are no longer with their husbands, they were once married. The finding however contrasts that of [28] that reported higher prevalence in single women.…”

Synchronous Appearance of a High-Grade Neuroendocrine Carcinoma of the Ampulla Vater and Sigmoid Colon Adenocarcinoma

“…Five patients had synchronous SPM including two colon cancers with one double colon cancer, one gastric cancer, one bladder cancer, and one ovarian cancer and nine metachronous SPM including two basal cell carcinomas, one colon cancer, two breast cancer, one gastric MALT-lymphomas, one ductal pancreatic adenocarcinoma, one bladder cancer, and one hepatocellular carcinoma [ 20 ]. In addition, a case was reported of a woman treated initially for a synchronous squamous cell carcinoma of the cervix and a basal cell carcinoma of the skin, who developed a third malignancy described as a neuroendocrine carcinoma of an unknown primary site [ 21 ]. Our patient has been diagnosed with basal cell skin carcinoma 15 years prior to the initial diagnosis of the synchronously described colon adenocarcinoma and neuroendocrine carcinoma.…”

Metachronous double malignancy involving the kidney and the breast: A case report

“…It is classified into two categories depending on the time of diagnosis of each primary site. Synchronous cancers occur at the same time or within an interval of two months, while metachronous cancers follow in sequence and more than two months apart [2]. The incidence has increased in recent years possibly secondary to improve survival in cancer patients [3].…”