Triple-Marker Prenatal Screening Program for Chromosomal Defects

Kazerouni, N. Neely; Currier, Bob; Malm, Linda; Riggle, Susan; Hodgkinson, C. Paul; Smith, Sylvia B.; Tempelis, Corinna; Lorey, Fred; Davis, Amber; Jelliffe‐Pawlowski, Laura L.; Walton-Haynes, Lynn; Roberson, Marie

doi:10.1097/aog.0b013e3181a9479e

Cited by 47 publications

(17 citation statements)

References 16 publications

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“…Women who underwent screening in the second trimester only were not included in our cohort, because these results have been previously reported. 3,4 Screen-positive interpretation qualified women for follow-up services at a state-approved Prenatal Diagnostic Center. Follow-up services include genetic counseling and diagnostic services such as chorionic villus sampling, second-trimester ultrasonography, and amniocentesis.…”

Section: Methodsmentioning

confidence: 99%

“…3 All chromosomal abnormalities included in this study were diagnosed by karyotype. Registry ascertainment sources include physicians, cytogenetic laboratories, hospitals, and prenatal diagnostic centers.…”

Section: Methodsmentioning

confidence: 99%

“…2 Detection rates for second-trimester screening in California have been previously reported. 3,4 This report summarizes outcomes for women who underwent first-trimester or sequential (first-and secondtrimester) screening. We estimate current detection and screen-positive rates for the target aneuploidies (trisomies 21 and 18) as well as nontargeted chromosomal abnormalities.…”

mentioning

confidence: 99%

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Detection Rates for Aneuploidy by First-Trimester and Sequential Screening

Baer

Flessel

Jelliffe‐Pawlowski

et al. 2015

Obstetrics &Amp; Gynecology

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Detection Rates for Aneuploidy by First-Trimester and Sequential Screening

Baer

Flessel

Jelliffe‐Pawlowski

et al. 2015

Obstetrics &Amp; Gynecology

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“…GDSP contracts with regional laboratories to analyse the serum biomarkers for gravid women who decide to participate. The laboratories use a uniform assay protocol that includes an automated analytical system [25,26].…”

Section: Methodsmentioning

confidence: 99%

A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations

et al. 2012

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The risk of abnormalities and morbidity among live births increases with advanced maternal age. Explanations for this elevated morbidity invoke several maternal mechanisms. The relaxed filter stringency (RFS) hypothesis asserts that mothers, nearing the end of their reproductive lifespan, reduce the stringency of a screen of offspring quality in utero based on life-history traits of parity and interbirth interval (IBI). A separate line of research implicates human chorionic gonadotropin (hCG) during pregnancy as a signal of offspring quality. We test the RFS hypothesis directly by examining whether the difference in gestational hCG across consecutive live births varies positively with the mother's number of previous live births but inversely with her most recent IBI. We applied multivariable regression methods to a unique dataset of gestational hCG for over 500 000 live births from 2002 to 2007. The difference in gestational hCG across mothers' consecutive live births varies positively with both mothers' parity and IBI. These associations remain similar among older mothers (35þ years). Findings support the RFS hypothesis for the parity expectation but not for the IBI expectation. Further evidence for the RFS hypothesis among contemporary human gestations would have to invoke screening mechanisms other than hCG.

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“…1 Indications for amniocyte karyotyping are advanced maternal age, abnormal maternal serum screening results, abnormal prenatal ultrasound findings, and known family history of chromosomal anomalies or hereditary diseases. 2,3 In recent years, Taiwanese women have married later and become pregnant at older ages. After the implementation of national health insurance, antenatal care usage also increased.…”

Section: Introductionmentioning

confidence: 99%