Triple negative breast cancer: heterogenous disease

Abstract

Triple-negative breast cancer (TNBC) is a distinct subset of breast cancer defined by the lack of immunohistochemical expression of estrogen and progesterone receptors and epidermal growth factor receptor 2. It is a heterogeneous disease and displays overlapping characteristics with both basal-like and brca 1-2 BCs. This review evaluates the activity of emerging target agent in TNBC.KEY WORDS: triple negative breast cancer, basal-like, heterogeneous disease, metastatic breast cancer.