Triple-negative breast cancer with calcified metastases of hepatic, portal vein and inferior vena cava: Report of a case and review of the literature

Wan, Chih-Kang; Chen, Ling-Ping; Chen, Hsin‐Yi; Yang, Sien–Sing; Hu, Jianhe

doi:10.1016/j.jfma.2020.03.020

Cited by 2 publications

(5 citation statements)

References 14 publications

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“…The most notable aspect about this case report is the initial aggressiveness and the atypical form with which the patient debuted, according to what is reported in the literature [3,4,8,11,12,14,15]. The most common initial clinical picture is the single breast nodule on TNBC, even less often (under 0.5%) [5].…”

Section: Discussionmentioning

confidence: 94%

“…Breast cancer ranks first in incidence and leading cause of death among women in the world [1][2][3][4][5][6]. In Pedregal Hospital in Mexico where it is observed during a period of 2009-2015 of 3,290 samples only 9.6% of the cases were BCTN cases [14]. Histologically, the most common BCTN is the Invasive Ductal Breast Carcinoma, other unusual BCTN are Apocrine and Adenoid cystic with better prognostic [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Atypical Presentation of Triple-Negative Breast Cancer

Garcia-Cahuich¹,

Rodríguez-Solis²,

García-Carrillo³

et al. 2021

Int J Cancer Clin Res

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CASE REpoRt ANd SYStEMAtiC REViEwCheck for updates one year, 2,261,419 million cases of cancer have been diagnosed, of which breast cancer represents 11.7% of all types of cancer with 684,996 deaths reported [1]. A patient suffering breast cancer has about 77 years of life expectancy and being diagnosed with an average of years of 52.5-years-old, being the majority diagnosed after 50-years-old, a 23% are found in those under 45-years-old [5,6].Only 10% of breast cancer cases have genetic background, being the majority, sporadic (90%) [5]. The definitive diagnostic is made by biopsy with positive results of malignancy classified by immunohistochemistry (IHC) depending by positivity of Estrogenic Receptors (ER), Progesterone Receptors (PR) and Epidermal growth factor receptor 2 (HER2) [4,6,7]. Immunohistochemistry classification is being classified by subtypes: Luminal A, Luminal B, HER2 positive and Triple-negative [7]. In Mexico, the incidence according to the IHC is of hormone receptors 60%, HER-2 positive 20.4% and triple-negative 23.1% [8].The Triple negative Breast Cancer (BCTN) it been defined as the absence of Estrogenic Receptors (ER), Progesterone Receptors (EP), Epidermal growth factor receptor 2 (HER2) [2,4,[8][9][10][11], and it conforms 10 to 20% of all cases of breast cancer [10,12,13]. It has been made a study by Acta Medica Grupo Angeles, in the Angeles Summary Introduction: Triple-Negative Breast Cancer (BCTN) has been defined as the absence of Estrogenic Receptors (ER), Progesterone Receptors (EP), Epidermal growth factor receptor 2 (HER2), and it conforms 10 to 20% of all cases of breast cancer.Case report: A 42-years-old female, debuting with abdominal pain, a 44 pounds of weight loss on the last 2 months and abdominal mass presence. A single complex looking nodule found in the left breast, which underwent a biopsy with results of triple negative breast adenocarcinoma, she had kidney failure, hypoglycemia and neurological impairment concluding in death.Discussion: Triple-Negative Breast Cancer occurs in young women, it has an aggressive development, it characterized by present brain metastasis giving to it an ominous prognostic.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Atypical Presentation of Triple-Negative Breast Cancer

Garcia-Cahuich¹,

Rodríguez-Solis²,

García-Carrillo³

et al. 2021

Int J Cancer Clin Res

View full text Add to dashboard Cite

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“…High ADC of the whole tumour or tumour periphery after N-acetylcysteine (NAC) correlates inversely with low tumour vitality [ 37 ]. No association was found between whole metastasis ADC and histology after NAC, but ADC of the periphery was higher for metastases with major histological response [ 38 ]. An elevation in ADC value is thought to present a higher degree of freedom of water molecules in the tissue, which can be due to increased necrosis and reduced cellularity [ 39 ].…”

Section: Tumour Response Assessment Based On the Other Criteriamentioning

confidence: 99%

“…Numerous malignant tumours, such as colorectal cancer, ovarian cancer, pancreatic cancer, thyroid cancer, osteosarcoma, and chondrosarcoma, are often associated with calcified liver metastases. There is rare documentation in the literature of breast cancer combined with calcified liver metastases [ 38 ].…”

Section: Tumour Response Assessment Based On the Other Criteriamentioning

confidence: 99%

“…It is generally accepted that the necrosis of tumour cells following systemic therapy like chemotherapy in the FOLFIRI (folinic acid [leucovorin], 5-fluorouracil, and irinotecan) protocol may result in subsequent inflammatory reactions that cause the metastatic lesions to calcify ( Figure 3 ). Thus, repeated growth and necrosis of tumour cells during systemic therapy may lead to calcified liver metastases [ 38 ]. The maximum calcification density and calcification morphology has no bearing on the effectiveness of treatment [ 10 ].…”

Section: Tumour Response Assessment Based On the Other Criteriamentioning

confidence: 99%

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Assessment of the response to systemic treatment of colorectal liver metastases on cross-sectional imaging – a systematic review

Morawska,

Cieszanowski

2023

Pol J Radiol

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Colorectal cancer (CRC) is one of the most common malignancies in the world. Nowadays many treatments are available to help control CRC, including surgery, radiation therapy, interventional radiology, and drug treatments. A multidisciplinary approach and the role of radiologists is needed to assist the surgeon in the management thanks to emerging technology and strategies. The Response Evaluation Criteria in Solid Tumours (RECIST) has been created to objectify and standardize cancer response assessment. Thus, in this article specific presumptions and practical aspects of evaluating responses according to the RECIST 1.1 are discussed. Furthermore, examples of possible response to systemic treatment of colorectal liver metastases (CRLM), including tumour necrosis, apparent diffusion coefficient (ADC) values, tumour calcification, tumour fibrosis and intratumoural fat deposition observed on cross-sectional imaging, are described. Disappearing liver metastases (DLM) presents a therapeutic dilemma. The optimal management of DLM remains controversial due to the uncertainty of residual microscopic disease and effective long-term outcomes. The article provides an overview of the CRLM phenomenon and current possible assessment methods of the response to systemic treatment.

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Triple-negative breast cancer with calcified metastases of hepatic, portal vein and inferior vena cava: Report of a case and review of the literature

Cited by 2 publications

References 14 publications

Atypical Presentation of Triple-Negative Breast Cancer

Atypical Presentation of Triple-Negative Breast Cancer

Assessment of the response to systemic treatment of colorectal liver metastases on cross-sectional imaging – a systematic review

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