Triple-Negative Breast Cancer with Dermatomyositis: A Case Report and Literature Review

Chen, Xiao; Chen, Anran; Liu, Chaoqi; Zhang, Bin

doi:10.2147/cmar.s349400

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Sentinel Lymph Node (SLN) is an initial axillary metastatic location for breast cancer. Metastasis to the next location of lymph node is less likely if SLN metastasis does not occur, however the definition of SLNB indication is lacking [6][7][8]. The prediction of axillary lymph node metastasis is significant for minimizing the unnecessary axillary lymph node dissection and enhancing the patients' prognosis [9].…”

Section: Introductionmentioning

confidence: 99%

The value of ultrasonic parameters combined with clinicopathological parameters in predicting axillary lymph node metastasis in triple-negative breast cancer

2023

European Journal of Gynaecological Oncology

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The clinical data of 119 patients with triple-negative breast cancer (TNBC) were retrospectively analyzed, and comparisons revealed that the differences between those who developed axillary lymph node metastasis and those who did not were statistically significant when comparing the age, histological grading of the lesions, expression of Ki-67, and information about the morphology of the lesions, internal blood flow, and the ultrasonographic manifestations of axillary lymph nodes on ultrasonography of the distribution of the lesions in the lesions’ quadrants (p < 0.05). Multifactorial regression analysis suggested that age, histological grade, lesion quadrant, and axillary lymph node ultrasound performance were all relevant factors affecting axillary lymph node metastasis in TNBC patients; the predictive model of axillary lymph node metastasis in TNBC was constructed with the results of multifactorial regression analysis, and the results of the ROC curve analysis showed that the logistic regression model had an AUC of 0.761 and the sensitivity and specificity were 0.824 and 0.714, respectively, for predicting the metastasis of the axillary lymph nodes in TNBC patients. This suggests that ultrasound combined with pathological parameters has some value in helping clinical judgment of axillary lymph node metastasis in TNBC patients.

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Section: Introductionmentioning

confidence: 99%

The value of ultrasonic parameters combined with clinicopathological parameters in predicting axillary lymph node metastasis in triple-negative breast cancer

2023

European Journal of Gynaecological Oncology

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Successful treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease complicated by bilateral breast cancer following the additional tofacitinib: A case report

Yamane,

Kitayama

2024

Modern Rheumatology Case Reports

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Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody-positive dermatomyositis (MDA5-DM) is known to cause rapidly progressive interstitial lung disease (RP-ILD). Cancer complications in MDA5-DM are less frequently reported compared to other forms of DM, though they do occur. The treatment strategy for DM with aspects of paraneoplastic syndrome is usually to treat the cancer first, if possible. However, surgery is difficult in the setting of respiratory failure and carries the risk of acute exacerbation of interstitial lung disease, as does chemotherapy and radiotherapy. The prognosis of MDA5-DM with RP-ILD has improved with initial immunosuppressive combination therapy, but certain cases remain refractory to treatment. Recently, the efficacy of janus kinase (JAK) inhibitors in refractory MDA5-DM cases has been reported. However, immunosuppressive therapies, including JAK inhibitors, may have negative effect on cancer progression. Here, we report a 48-year-old woman suffering from MDA5-DM with RP-ILD complicated by bilateral breast cancer. Due to respiratory failure, radical breast cancer surgery and chemotherapy could not be performed, so endocrine therapy and combined immunosuppressive therapy were first administered. However, the patient’s condition was refractory to this initial treatment. Therefore, tofacitinib in combination with plasma exchange therapy was initiated, leading to an improvement in ILD, and bilateral mastectomy could be performed. One year later, MDA-5 antibody titers became negative, and glucocorticoid was successfully discontinued after two years. To date, three years have passed without recurrence of either MDA5-DM or breast cancer. To our knowledge, this is the first report of MDA5-DM complicated by breast cancer, as well as the first case of JAK inhibitor use for MDA5-DM with cancer. For curative treatment of MD5-DM with RP-ILD, if comorbid cancers are found, collaboration with oncologists to balance the efficacy and adverse events of MDA5-DM with RP-ILD therapy is essential in determining the appropriate type and timing of treatment, which could lead to a favorable outcome.

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Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites

Guo,

Wang,

Wang

et al. 2024

J Nanobiotechnol

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death, has attracted attention and shown potential application value in anti-tumor therapy [7][8][9].Hesperetin is a natural flavonoid compound found in citrus fruit peels with multiple biological activities [10][11][12]. Previous studies have shown that hesperetin exhibits anti-proliferation, anti-invasion, and pro-apoptosis activities in various cancers [13][14][15]. However, the antitumor effects of hesperetin in TNBC and its mechanisms of action remain unclear [16,17].Iron plays an important role in tumor cells, including cell proliferation, redox homeostasis, and tumor development [18,19]. Ferroptosis is a mechanism that induces cell death by regulating intracellular iron ion metabolism and oxidative reduction processes [20,21]. Recent studies have shown that promoting ferroptosis in tumor cells may serve as a novel tumor treatment strategy [19].

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Triple-Negative Breast Cancer with Dermatomyositis: A Case Report and Literature Review

Cited by 3 publications

References 28 publications

The value of ultrasonic parameters combined with clinicopathological parameters in predicting axillary lymph node metastasis in triple-negative breast cancer

The value of ultrasonic parameters combined with clinicopathological parameters in predicting axillary lymph node metastasis in triple-negative breast cancer

Successful treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease complicated by bilateral breast cancer following the additional tofacitinib: A case report

Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites

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