Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

Li, Jia Wei; Zhang, Kai; Shi, Zhao Ting; Zhang, Xun; Xie, Juan; Liu, Jun Ying; Chang, Cai

doi:10.1038/s41598-018-27222-6

Cited by 36 publications

(55 citation statements)

References 36 publications

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“…In these studies, histologic grade did not differ between LAR-TNBC and control group, whereas we observed a lower percentage of poorly differentiated tumors in our group of LAR-TNBC. Lower histological grading and slower growth can be associated with a more spiculated, infiltrating growth pattern, giving the surrounding tissue time for stromal interactions (7). This may explain our mammographic findings; however, they seem to be contradictory to the more frequent lobular sonographic patterns of LAR in our study.…”

Section: Figure 2 Ultrasound Images Of Bl-tnbc With Lobulated Margincontrasting

confidence: 68%

“…Several features of mammographic and sonographic breast findings are evaluated algorithmically to minimize radiologist-dependent subjective ratings. TNBC is known to present more often benign characteristics in clinical imaging such as lobulated, oval-shaped, and circumscribed margins, than other types of BC (7). Benign classification and misinterpretation can lead to diagnostic delay and negative impact on the outcomes of BC (8).…”

Section: Conclusion: the Histopathological Subtype Of Tnbc Influencesmentioning

confidence: 99%

“…TNBC is known to present a benign appearance more often in mammogram and ultrasound than non-TNBC (7,14). Due to the heterogeneous pattern of TNBC especially in ultrasound, some authors have concluded that the predictive value of sonographic appearance might be low when comparing TNBC versus non-TNBC (7).…”

Section: Figure 2 Ultrasound Images Of Bl-tnbc With Lobulated Marginmentioning

confidence: 99%

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Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer

et al. 2020

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BACKGROUND/AIM Triple-negative breast cancer (TNBC) can be divided into subtypes of basal-like (BL), mesenchymal-like (ML), luminal androgen receptor (LAR), and immunomodulatory (IM). The aim of our study was to assess whether there are distinct radiologic features within the different TNBC subtypes and whether this has potential clinical impact. PATIENTS AND METHODS Imaging pictures of 135 patients with TNBC were re-evaluated. TNBC subtyping was performed on asservated tumor tissue using a panel of antibodies. RESULTS Mammographic margins of LAR-TNBC were more often spiculated (24.3% versus 0-4.1%). BL-TNBC presented more frequent a mass without calcification in mammogram than other subtypes (71.4% versus 48.6-57.9%). In ultrasound, ML and LAR were described more often with smooth borders. CONCLUSION The histopathological subtype of TNBC influences its presentation in ultrasound and mammogram. This can reflect a different growth pattern of the subtypes and may have an impact on the early diagnosis of TNBC.

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Section: Figure 2 Ultrasound Images Of Bl-tnbc With Lobulated Margincontrasting

confidence: 68%

Section: Conclusion: the Histopathological Subtype Of Tnbc Influencesmentioning

confidence: 99%

Section: Figure 2 Ultrasound Images Of Bl-tnbc With Lobulated Marginmentioning

confidence: 99%

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Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer

et al. 2020

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“…A total of 620 patients with TNBC, with ages ranging from 28 to 95 years, were included in the analysis. Of the included studies, 8 studies focused on the evaluation of the tumor shape of TNBC, all of which showed that the occurrence rate of a “round/oval shape” in TNBC was higher than that in non‐TNBC. Of the included studies, there were 7 studies evaluating the tumor margin of TNBC.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta‐analysis of the Malignant Ultrasound Features of Triple‐Negative Breast Cancer

Tian

Wang

Qin

et al. 2020

J of Ultrasound Medicine

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Objectives-The malignant ultrasound (US) features of breast cancer are known to include an irregular shape, a noncircumscribed margin, an echogenic halo, a nonparallel orientation, posterior acoustic attenuation, microcalcification, and others. However, these US features are uncertain and controversial for the diagnosis of triple-negative breast cancer (TNBC). This study aimed to analyze the diagnostic value of malignant US features for TNBC by a systematic review and meta-analysis, analyze the US characteristics of TNBC, and provide US evidence for clinical diagnosis. Methods-A comprehensive search was performed to identify relevant English articles concerning the US diagnosis of TNBC (from the date of database establishment to November 2019). The pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio with 95% confidence interval, summary receiver operating characteristic curve, and area under the curve for the different malignant US features were calculated. Results-Ten studies (620 patients) met the eligibility criteria. The sensitivity (range, 0.14-0.68) and specificity (range, 0.19-0.66) of the malignant US features were not high. Summary receiver operating characteristic curves showed that the area under the curve (range, 0.25-0.47) of the malignant US features was low, demonstrating that these features have poor diagnostic value for TNBC. The positive likelihood ratio (range, 0.4-to 0.9) of the malignant US features was low, and the negative likelihood ratio (range, 1.09-2.02) was not low, revealing that these features had a poor ability to confirm or exclude TNBC. Conclusions-Triple-negative breast cancer lacks the typical malignant US features of breast cancer and has its own US features. Key Words-malignant ultrasound features; meta-analysis; systematic review; triple-negative breast cancer B reast cancer is one of the most common malignant tumors in women. Its incidence is rapidly rising in most countries. 1-3 Triple-negative breast cancer (TNBC) is a distinct subtype of breast cancer that lacks the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by high malignancy, poor tissue differentiation, and strong invasive ability. 4-6 Therefore, the early diagnosis of TNBC is very important to provide appropriate therapy. Endocrine therapies and targeted therapies are ineffective for TNBC. Some studies have shown that patients with TNBC are more likely to have a complete pathologic response with neoadjuvant chemotherapy than those without TNBC. 7,8 At present, the diagnosis of

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“…It was hypothesized that those lesions mimicked the morphology of benign lesions because of their rapid cellular proliferation. [30][31][32] One of the most interesting findings of our study was the association between sonographic orientation and molecular subtypes in predicting BC outcomes. This may be explained by diverse imaging patterns among different molecular subtypes of BC.…”

Section: Discussionmentioning

confidence: 71%

Association of sonographic features and molecular subtypes in predicting breast cancer disease outcomes

et al. 2020

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Background Features in preoperative ultrasound could predict the prognosis of triple‐negative breast cancer (TNBC), while its prognostic value in other molecular subtypes of breast cancer (BC) was unknown. The study aimed to assess the prognostic value of preoperative sonographic features, including orientations, on long‐term outcomes in BC and its association with different molecular subtypes. Methods Women diagnosed with invasive BC > 5 mm who underwent surgery were retrospectively reviewed. Clinical, pathological, and sonographic profiles were collected and recurrence‐free survival (RFS) and breast cancer‐specific survival (BCSS) were reported. Interactions between clinicopathological features and tumor orientations in predicting RFS and BCSS were analyzed. Competing risk model was performed to estimate prognostic values of sonographic features for RFS and BCSS. Results A total of 2812 patients were included. With a median follow‐up of 60.0 months, 268 (9.5%) patients suffered from recurrences and 104 (3.7%) died of BC. The prognostic values of vertical orientation in predicting RFS (P = .001) and BCSS (P = .001) were strongly associated with molecular subtypes. Non‐TNBC tumors with vertical orientation had less recurrence events compared with parallel orientation (6.3% vs 8.7%, P = .035), whereas failed to predict disease outcomes in multivariate analysis (P > .05). Oppositely, in TNBC, vertical orientation was associated with worse RFS (HR = 3.50; 95% confidence interval [CI] 1.69‐7.24; P < .001) and BCSS (HR = 6.36; 95% CI 2.86‐14.14; P < .001) in multivariate analysis with a 5‐year RFS and BCSS of 73.4% and 74.6%. Meanwhile, vertical orientation was related with smaller tumor size (P < .001), human epidermal growth factor receptor 2 nonamplification (P < .001), and lower Ki‐67 expression (P = .001) among non‐TNBC population, whereas TNBC tumors with vertical orientation had a higher burden of axillary lymph node metastases (2.8 ± 1.0 vs 1.4 ± 0.2, P = .001). Conclusions Prognostic values of sonographic orientation in predicting BC disease outcomes were associated with molecular subtypes. Vertical orientation in preoperative sonogram may serve as a prognostic biomarker for TNBC patients.

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Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

Cited by 36 publications

References 36 publications

Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer

Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer

Systematic Review and Meta‐analysis of the Malignant Ultrasound Features of Triple‐Negative Breast Cancer

Association of sonographic features and molecular subtypes in predicting breast cancer disease outcomes

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