Triple Overlap Between Silicosis, Dermatomyositis, and Systemic Sclerosis

Jain, Siddharth; Samanta, Joydeep; Vyas, Surabhi; Mahajan, Shalvi; Suri, Vaishali; Kumar, Uma

doi:10.1097/rhu.0000000000001371

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Numerous studies have shown that autoantibodies increase with excessive exposure to mineral dust, including antinuclear antibodies (ANA), rheumatoid factor (RF), antineutrophil cytoplasmic antibodies (ANCA) and so on. [5][6][7] In addition, various studies have demonstrated that connective tissue disease (CTD) can be complicated in patients with pneumoconiosis, [8][9][10][11][12][13][14][15] such as Caplan's syndrome and Erasmus syndrome, which have been reported histologically. 16 17 In these pneumoconiosis patients, though the incidence of CTD is markedly lower than the incidence of positive autoantibodies, it is not known if patients with positive autoantibodies will develop CTD later.…”

Section: Introductionmentioning

confidence: 99%

Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study

Wang

et al. 2023

BMJ Open

View full text Add to dashboard Cite

ObjectiveTo describe the prevalence, clinical features and potential risk factors of pneumoconiosis in combination with connective tissue disease (CTD) or positive autoantibodies.DesignCross-sectional study.SettingA retrospective study of adults recruited in China between December 2016 and November 2021.ParticipantsA total of 931 patients with pneumoconiosis at Beijing Chao-Yang Hospital were enrolled in this study; of these, 580 patients were included in the final analysis.Main outcome measuresPneumoconiosis combined with CTD or positive autoantibodies was a major adverse outcome.ResultsIn total, 13.8% (80/580) of the patients had combined pneumoconiosis with CTD, among whom the prevalence of CTD was 18.3% (46/251) in asbestosis and 11.4% (34/298) in silicosis/coal mine workers’ pneumoconiosis. In comparison to the general Chinese adult population, the relative risk of various CTD in pneumoconiosis, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary Sjögren’s syndrome, idiopathic inflammatory myopathy and antineutrophil cytoplasmic antibodies-associated vasculitis, were 11.85, 12.12, 127.40, 4.23, 9.94 and 644.66, respectively. Multivariate analysis revealed that female sex (OR 2.55, 95% CI 1.56 to 4.17) and a later stage of pneumoconiosis (OR 2.04, 95% CI 1.24 to 3.34) were the independent risk factors for CTD in patients with pneumoconiosis (all p<0.050).ConclusionCTD is highly prevalent in patients with pneumoconiosis, especially in patients of asbestosis, and silicosis/coal mine workers’ pneumoconiosis. Female sex and later stages of pneumoconiosis are associated with an increased risk of combined with CTD.

show abstract