In this chapter, firstly we apply the iterative method to establish the existence of the positive solution for a type of nonlinear singular higher-order fractional differential equation with fractional multi-point boundary conditions. Explicit iterative sequences are given to approximate the solutions and the error estimations are also given. Secondly, we cover the multi-valued case of our problem. We investigate it for nonconvex compact valued multifunctions via a fixed point theorem for multivalued maps due to Covitz and Nadler. Two illustrative examples are presented at the end to illustrate the validity of our results.