Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism

Lefkou, Eleftheria; Varoudi, Katerina; Pombo, Joaquim; Jurisic, A.; Jurisic, Z.; Contento, Greg; Girardi, Guillermina

doi:10.1016/j.bcp.2020.114217

Cited by 19 publications

(25 citation statements)

References 39 publications

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“…The umbilical artery test with Doppler from the 26th week until childbirth offers great help, while for the same period of time a weekly cardiotocographic test (non-stress test) should be performed, as well as an ultrasound control of the amount of amniotic fluid. The most commonly used regimen involves the administration of aspirin (80 mg daily) and heparin, either crystalline or low molecular weight, in prophylactic doses [60][61][62][63][64].…”

Section: When Will We Check a Patient For Aplsmentioning

confidence: 99%

“…Coumarin is not administered particularly in the 1st and 3rd trimesters as potential teratogens and due to easy passage through the placenta coagulation disorders in the fetus and because they are associated with greater maternal morbidity. Their administration is indicated only in rare cases of contraindication to heparin or aspirin [60][61][62][63][64][65][66][67][68].…”

Section: When Will We Check a Patient For Aplsmentioning

confidence: 99%

“…Complications of anticoagulant therapy in pregnancy include embryopathy (nasal hypoplasia, spotted epiphyses), CNS abnormalities (Dandy-Walker syndrome, visual atrophy), fetal bleeding, hemorrhagic manifestations, skin allergies, thrombocytopenia and osteoporosis [60][61][62][63][64][65][66][67][68][69][70][71][72].…”

Section: When Will We Check a Patient For Aplsmentioning

confidence: 99%

“…Treatment should be applied only when the risk of complications is considered to be higher and after a thorough discussion with the pregnant woman. The prognostic factors of poor outcome are the title of anticardiolipin antibodies and the obstetric history [60][61][62][63][64][65][66][67][68][69][70][71][72].…”

Section: When Will We Check a Patient For Aplsmentioning

confidence: 99%

“…Until now, there are no final conclusions regarding the efficacy of the above therapy as monotherapy. Hydroxychloroquine inhibits aPL-B2GPI complexes on phospholipid surfaces, annexin A5, TF tissue factor, TLPs Toll-like receptors, statins such as pravastatin inhibition of Nuclear factor kappa B (NF-κB) is protein transcription factor, Anti-CD20 monoclonal antibodies (mAbs) resistant APS and aspirin are recommended to prevent and treat preeclampsia [60][61][62][63][64][65][66][67][68][69][70][71][72].…”

Section: When Will We Check a Patient For Aplsmentioning

confidence: 99%

See 4 more Smart Citations

Antiphospholipid Syndrome and Pregnancy-Diagnosis, Complications and Management: An Overview

Tsikouras¹,

Tsiggalou²,

Bothou³

et al. 2022

Inflammation in the 21st Century

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Antiphospholipid syndrome which is also known as APS is an autoimmune disease which represents an acquired form of thrombophilia. The etiology of APS remains unknown. This disorder occurs when the immune system mistakenly attacks some of the normal human proteins and manifests itself as recurrent arterial or venous thrombosis and it could emerge after abortions or in recurrent pregnancy loss. In APS, the body produces the wrong antibodies against phospholipid-binding proteins, that is present in the blood and plays an important role in coagulation. Antibodies are specific proteins that usually target and neutralize the body’s invaders, such as viruses and bacteria. When antibodies attack phospholipid-binding proteins, blood clots abnormally. Specifically, it could cause blood clots in veins or arteries leading to stroke and various pregnancy complications such as: endometrial death, miscarriage, preeclampsia, intrauterine growth restriction and prematurity. APS is divided into primary and secondary, which is associated with autoimmune diseases and more often with systemic lupus erythematosus (SLE), while antibodies against cardiolipin are detected in many other conditions (infections, malignancies, drugs, etc.). The symptoms of APS, in addition to arterial and/or venous thrombosis and pregnancy complications, are multisystemic and the differential diagnosis of the primary APS from the secondary, in the context of SLE, is of particular clinical interest and is subject of this literature review.

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Section: When Will We Check a Patient For Aplsmentioning

confidence: 99%