Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor

Otter, Maarten; Campforts, Bea; Stumpel, Constance T. R. M.; Amelsvoort, Thérèse van; Drukker, Marjan

doi:10.1192/j.eurpsy.2022.2355

Eur. Psychiatr.

2022

DOI: 10.1192/j.eurpsy.2022.2355

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Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor

Maarten Otter

Bea Campforts

Constance T. R. M. Stumpel

et al.

Abstract: This peer-reviewed article has been accepted for publication but not yet copyedited or typeset, and so may be subject to change during the production process. The article is considered published and may be cited using its DOI.

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2024

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Brain structure in Triple X syndrome: Regional gray matter volume and cortical thickness in adult women with 47,XXX karyotype

Domes,

Croyé,

Freilinger

et al. 2024

Preprint

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Background Changes in the brain structure of women with Triple X syndrome (karyotype 47,XXX) have been described in a few studies to date, including reduced total brain volume and regional reductions in gray substance in cortical and subcortical areas. Methods Using voxel-based morphometry (VBM) and surface-based morphometry (SBM), we investigated regional gray matter changes in a sample of n = 20 adult women with 47,XXX karyotype using T1-weighted 3T MRI scans. Results Compared to an age- and education-matched control group, the VBM revealed decreased regional gray matter volumes in the hippocampus, amygdala, parts of the basal ganglia, insula, prefrontal areas and cerebellum. To a lesser extent, we also noted specific reductions in cortical thickness in a smaller part of those regions. Conclusion This network is significantly involved in the processing of cognitive, affective, and social stimuli and is a potential neuronal correlate of the autism-like social-cognitive problems described in 47,XXX in the literature.

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Brain structure in Triple X syndrome: Regional gray matter volume and cortical thickness in adult women with 47,XXX karyotype

Domes,

Croyé,

Freilinger

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor

Abstract: This peer-reviewed article has been accepted for publication but not yet copyedited or typeset, and so may be subject to change during the production process. The article is considered published and may be cited using its DOI.

Cited by 1 publication

References 44 publications

Brain structure in Triple X syndrome: Regional gray matter volume and cortical thickness in adult women with 47,XXX karyotype

Brain structure in Triple X syndrome: Regional gray matter volume and cortical thickness in adult women with 47,XXX karyotype

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