Triplet‐Triplet Annihilation Upconversion‐Based Photolysis: Applications in Photopharmacology

Abstract

The emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off‐target toxicity outside the disease location of many drugs for the treatment of a given pathology. The use of photolytic reactions looks very attractive for a light activated drug release but requires to develop photolytic reactions sensitive to red or NIR light excitation for better tissue penetration. In this review, we will present the concepts of triplet‐triplet annihilation upconversion (TTA‐UC) based photolysis and their recent in vivo applications for light induced drug delivery using photoactivatable nanoparticles (NPs).This article is protected by copyright. All rights reserved

In Vivo Optogenetic Manipulation of Transgene Expression in Retinal Neurovasculature

“…Previous modifications of 4-OHT using o- nitrobenzyl , or coumarinyl photoremovable protecting groups required UV irradiation under 400 nm for photolysis. During the past decade, however, breakthroughs in photosensitive protection chemistry have allowed efficient uncaging at wavelengths around 450 nm and higher. − We thus devised a new strategy for the synthesis of caged 4-OHT with optimized excitation in the visible range for in vivo applications. We previously developed a new photoremovable group, 2-(4′-(bis(2-(2-methoxyethoxy)ethyl)amino)-4-nitro-[1,1′-biphenyl]-3-yl)propan-1-ol (EANBP, 1 ) .…”