This paper presents the comparison over the nuclear analysis of the European DEMO with HCLL blanket carried out with the TRIPOLI-4 ® Monte Carlo code and the JEFF-3.1.1 nuclear data library and with the MCNP5 Monte Carlo code and the FENDL-2.1 nuclear data library. The MCNP5 analysis was conducted firstly by ENEA with a detailed 3D model describing all the HCLL blanket internal structures. This MCNP5 model was converted into TRIPOLI-4 ® representation for performing the nuclear analysis at CEA with the objective to demonstrate consistency between both analyses. A very good agreement was obtained for all of the relevant nuclear responses (neutron wall loading, tritium breeding ratio, nuclear heating, neutron flux distribution, etc.), validating CEA's nuclear analysis approach, based on TRIPOLI-4 ® Monte Carlo code and JEFF-3.1.1 nuclear data library, for the European DEMO.