Triptan Use as a Function of Cardiovascular Risk. A Population‐Based Study

Bigal, Marcelo E.; Golden, Wendy L.; Buse, Dawn C.; Chen, Ya Ting; Lipton, Richard B.

doi:10.1111/j.1526-4610.2009.01595.x

Cited by 29 publications

(30 citation statements)

References 36 publications

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“…Similar results were obtained for subjects with migraine with aura and migraine without aura overall (3, 26). In the same population, the prevalence of diabetes did not differ between subjects with episodic and chronic migraine (27).…”

Section: Discussionsupporting

confidence: 82%

Migraine and risk of incident diabetes in women: A prospective study

et al. 2012

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Background Previous cross-sectional studies evaluating the relationship between diabetes prevalence and migraine status have found conflicting results. We examined the relationship between migraine and incident type 2 diabetes (T2D) in a cohort of adult women. Methods Prospective cohort study conducted among participants in the Women’s Health Study who provided information on migraine and did not have diabetes at baseline. Our four exposure groups were migraine with aura, migraine without aura, past history of migraine and no history of migraine. Cox proportional hazards models were used to determine the hazard ratio for incident T2D. Results Among the 38,620 women included in this study, 5062 (13.1%) women had migraine, of whom 2014 (39.8%) reported migraine with aura, and 2,087 (5.4%) women had a past history of migraine. During a mean of 14.6 years of follow-up, there were 3,032 cases of incident T2D. After adjustment for confounders, the hazard ratio (95% confidence interval) for developing diabetes was 1.06 (0.91–1.24) for women with migraine with aura, 1.01 (0.89–1.16) for women with migraine without aura, 1.13 (0.98–1.30) for women with a past history of migraine compared to women with no history of migraine. Conclusion Results of this prospective study in women do not support an association between migraine and incident T2D.

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Section: Discussionsupporting

confidence: 82%

Migraine and risk of incident diabetes in women: A prospective study

et al. 2012

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“…This is consistent with published research in which the risk of CV risk factors among adults with migraine is higher than those without migraine [14, 15]. Bigal et al reported that the prevalence rate of CV risk factors such as diabetes (12.6%), hypertension (33.1%), hyperlipidemia (32.7%), and smoking (15.8%) was significantly higher among adults with migraine as compared to adults without migraine [10]. …”

Section: Discussionsupporting

confidence: 90%

“…The AMPP study reported that triptans use among those with no CV risk factors was 18.3% [10]. The difference in rates of triptans use may be due to differences in study population and the definition of CV risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Little is known about the rates of triptans use among adults with CV risk factors. Only the American Migraine Prevalence and Prevention (AMPP) study examined triptans use among adults with CV risk factors [10]. This study found that triptans are less likely to be used by individuals with diabetes, hypertension, and smokers as compared to those without diabetes and hypertension and those who are nonsmokers.…”

Section: Introductionmentioning

confidence: 99%

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Triptans Use for Migraine Headache among Nonelderly Adults with Cardiovascular Risk

Alwhaibi

Deb

Sambamoorthi

2016

Pain Research and Treatment

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Objective. To examine the association between the cardiovascular (CV) risk factors and triptans use among adults with migraine. Methods. A retrospective cross-sectional study design was used. Data were derived from 2009–2013 Medical Expenditure Panel Survey (MEPS). The study sample consisted of adults (age > 21 years) with migraine headache (N = 1,652). Multivariable logistic regression was used to examine the relationship between CV risk factors and triptans use. Results. Overall, 21% adults with migraine headache used triptans. Nearly two-thirds (61%) of adults with migraine had at least one CV risk factor. A significantly lower percentage of adults with CV risk (18.1%) used triptans compared to those without CV risk factors (25.5%). After controlling for demographic, socioeconomic status, access to care, and health status, adults with no CV risk factors were more likely to use triptans as compared to those with one CV risk factor (AOR = 1.83, 95% CI = 1.17–2.87). There were no statistically significant differences in triptans use between those with two or more CV risk factors and those with one CV risk factor. Conclusion. An overwhelming majority of adults with migraine had a contraindication to triptans based on their CV risk factors. The use of triptans among adults with migraine and multiple CV risk factors warrants further investigation.

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“…Migraine is intimately linked to cardiovascular disease (CVD) . Migraine, particularly migraine with aura, is a risk factor for CVD events, including myocardial infarction and stroke, and is associated with increased cardiovascular (CV) mortality .…”

Section: Introductionmentioning

confidence: 99%