Tripterygium wilfordii var. regelii which are interleukin-1 inhibitors

Shishido, Kozo; Nakano, K.; Wariishi, Noriko; Tateishi, Hideo; Omodani, Tomoki; Shibuya, Masayuki; Goto, Kumiko; Ono, Yukihisa; Takaishi, Yoshihisa

doi:10.1016/s0031-9422(00)90596-x

Cited by 49 publications

(26 citation statements)

References 12 publications

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“…Previous studies have shown the anticancer activities of some sesquiterpenes such as triptofordin F-2, triptogelin A-1, and triptogelin C-1 from T. regelii [41]. Furthermore, diterpene quinoids, triptoquinones A-F isolated from T. regelii have been reported to have anti-inflammatory activities [34,42]. These studies have demonstrated the potential of TRE to reduce inflammation and autoimmune responses.…”

Section: Discussionmentioning

confidence: 89%

“…These results suggest that TRE could be a prominent natural source of strong antioxidant compounds. Although the composition of TRE extract remains to be elucidated, previously a number of triterpenes, diterpenes, sesquiterpenes and alkaloids as a major compound have been isolated from this plant and their biological activities have been documented [15,[33][34][35][36][37][38][39]. Several studies have shown that celastrol, a quinone methide triterpenoid isolated from T. regelii, possesses various biological properties including chemopreventive, antioxidant, neuroprotective and anti-inflammatory actions [33,37,38].…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

et al. 2010

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The present work was conducted to investigate the antioxidant activity and neuroprotective effects of Tripterygium regelii extract (TRE) on H(2)O(2)-induced apoptosis in human dopaminergic cells, SH-SY5Y. TRE possessed considerable amounts of phenolics (282.73 mg tannic acid equivalents/g of extract) and flavonoids (101.43 mg naringin equivalents/g of extract). IC(50) values for reducing power and DPPH radical scavenging activity were 52.51 and 47.83 microg, respectively. The H(2)O(2) scavenging capacity of TRE was found to be 57.68 microM x microg(-1) min(-1). By examining the effects of TRE on SH-SY5Y cells injured by H(2)O(2), we found that after incubation of cells with TRE prior to H(2)O(2) exposure, the H(2)O(2) induced cytotoxicity was significantly reversed and the apoptotic features such as change in cellular morphology, nuclear condensation and DNA fragmentation was inhibited. Moreover, TRE was very effective attenuating the disruption of mitochondrial membrane potential and apoptotic cell death induced by H(2)O(2). TRE extract effectively suppressed the up-regulation of Bax, Caspase-3 and -9, and down-regulation of Bcl-2. Moreover, TRE pretreatment evidently increased the tyrosine hydroxylase (TH) and brain-derived neurotrophic factor (BDNF) in SH-SY5Y cells. These findings demonstrate that TRE protects SH-SY5Y cells against H(2)O(2)-induced injury and antioxidant properties may account for its neuroprotective actions and suggest that TRE might potentially serve as an agent for prevention of neurodegenerative disease associated with oxidative stress.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

et al. 2010

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“…13 and 14)-Benzoquinones in general were found to inhibit NF-κB activation, possibly by interfering with one or more of the redox systems involved in activation (Niwa et al, 1997). Triptoquinones A-F (47-52) reduced release of IL-1α and IL-1β (Takaishi et al, 1992b;Shishido et al, 1994). Triptoquinone A (=triptoquinonoic acid A) (47) inhibited NO formation by two types of NO synthases in rat thoracic aorta (Kida et al, 1998).…”

Section: Insecticidal Activitymentioning

confidence: 99%

“…Suppression of NO formation was due to inhibition of induction of the mRNA for iNOS rather than to inhibition of iNOS activity (Niwa et al, 1996). Triptoquinone A (47) appears to be a competitive antagonist of leukotriene D 4 (Xu et al, 1997) and was effective in the adjuvant-induced arthritic rat model (Takaishi et al, 1992b;Shishido et al, 1994). Also, 47 and triptoquinone B (48) inhibited growth of P-388 leukemia cells in vitro (Zhou, 1991;Shen and Zhou, 1992a).…”

Section: Insecticidal Activitymentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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“…Compounds triptoquinone A-G were first isolated from the stems of Tripterygium wilfordii var. regelii by Shishido et al [17]. Six years after Shishido's discovery, Fujita et al [18] found triptoquinone H in the root bark of Tripterygium hypoglaucum.…”

Section: Triptoquinone Constituents From Genus Tripterygiummentioning

confidence: 99%

Molecular docking analysis of triptoquinones from genus Tripterygium with iNOS and in silico ADMET prediction

Tao

Yang

et al. 2019

SN Appl. Sci.

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This paper presents an investigation on the binding interaction of triptoquinones identified from genus Tripterygium to iNOS. In silico methods are adopted to predict ADME parameters, pharmacokinetic properties, drug-likeliness and acute toxicity of these identified compounds. A total of 20 triptoquinones are currently identified from genus Tripterygium. Most of these triptoquinones are found to bind to the key human iNOS residues involved in inhibitor binding. All the compounds are considered having drug-likeliness properties with no violation against Lipinski's "rule of 5" and are under safe category when administered orally. Twelve out of the 20 triptoquinones are predicted as passively crossing the blood-brain barrier. Eight of the given compounds are predicted to be pumped out by the p-glycoprotein. CYP2C19 and CYP2C9 are the significant isoforms influenced by the investigated triptoquinones from genus Tripterygium. As a result, triptoquinone ingredients from genus Tripterygium may be promising candidates for the development of drugs preventing inflammatory diseases.

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Tripterygium wilfordii var. regelii which are interleukin-1 inhibitors

Cited by 49 publications

References 12 publications

Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Molecular docking analysis of triptoquinones from genus Tripterygium with iNOS and in silico ADMET prediction

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