Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

Abstract

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.

Controlled Release Study of Metformin Using Trithiocyanuric Acid Functionalized MCM‐41 as a Nanocarrier

“…[4][5][6][7][8][9] Ordered mesoporous silica like LUS-1, MCM-41, and SBA-15 have a great potential for application in many fields such as catalysis, [10] preconcentration of metals, [11,12] dye removal [13,14] and drug delivery. [15][16][17][18][19][20] These materials have been considered due to their good biocompatibility, suitable surface charge, low cytotoxicity, and many possibilities for organic functionalization. Some of their properties make them suitable for use in drug delivery systems.…”

“…Different materials designs have been established as a carrier for drug delivery, mainly based micelles, polymers, nanoparticles, liposomes, and mesoporous compounds [4–9] . Ordered mesoporous silica like LUS‐1, MCM‐41, and SBA‐15 have a great potential for application in many fields such as catalysis, [10] preconcentration of metals, [11,12] dye removal [13,14] and drug delivery [15–20] . These materials have been considered due to their good biocompatibility, suitable surface charge, low cytotoxicity, and many possibilities for organic functionalization.…”