Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity

Abstract

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DNA/bovine serum albumin binding and cytotoxicity of transition metal ternary complexes based on sulfamethazine and bromazepam drugs

“…Here, the affinity of BSA towards our complexes was investigated by tracking the changes in the electronic absorption spectra of the complexes. [ 42,43 ] Protein titration plots of compounds 1–3 are shown in Figure 6. The spectral changes upon the addition of BSA to the solutions of the complexes were tracked at 266, 264 and 288 nm for 1 – 3 , respectively.…”

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

“…In continuation of our investigations to provide further insights into the therapeutic properties of metal-based compounds [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] , [118] , we herein highlight the recent progress conducted on the potential therapeutic applications of AMSs. This review begins with mechanistic concepts of AMS-catalyzed nucleic acids cleavage ( Section 2 ), followed by model substrates and instrumentations employed in cleavage studies ( Section 3 ).…”

“…These inheritable small DNA molecules are routinely found in prokaryotes and typically carry genes of secondary metabolism. Plasmids have a wide range of lengths, roughly from 1 to 100 kbp [96] , [99] , [108] , [115] .…”

Síntese e avaliação do potencial antitumoral de complexos de cobre(II) e níquel(II) contendo ligantes de interesse biológico

“…However, we have shown that diketone complexes are selective (selectivity index > 3) and that phenanthroline and its derivatives are not selective or active for some cell lines [5,8]. As to the MCF-7 cells, the complexes reported here possess similar or higher activity when compared to other nickel complexes already described [26][27][28][29].…”

“…VENKATA RAMANA REDDY, 2018;ANJOMSHOA et al, 2019;DEVI et al, 2019;. (LI et al, 2014;KAZEMI et al, 2015;BARRA et al, 2016) REHMAN et al, 2015).…”