Tris(ethylenediamine)nickel(II) thio-hydroxogermanate monohydrate: Synthesis, crystal structure, 1H NMR, EPR, optical and magnetic properties

Alahmari, Fatimah; Davaasuren, Bambar; Emwas, Abdul‐Hamid; Costa, Pedro M. F. J.; Rothenberger, Alexander

doi:10.1016/j.ica.2019.01.019

Cited by 15 publications

(13 citation statements)

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“…Typically, the resulting spectra consist only of broad and unresolved resonances because there are strong dipolar coupling effects, chemical shift anisotropy, and inherent magnetic susceptibility differences. Although, the main reason for the broad lines in tissue samples is the presence of magnetic susceptibility gradients [174,175,176]. Thus, when done properly, NMR can also be performed on semisolid tissue samples [177,178,179,180,181,182] with the use of high-resolution magic-angle spinning HRMAS spectroscopy [31,183,184,185].…”

Section: New Nmr Methods In Metabolomicsmentioning

confidence: 99%

NMR Spectroscopy for Metabolomics Research

et al. 2019

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Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the three principal analytical techniques used in metabolomics (the other two being gas chromatography coupled to mass spectrometry (GC-MS) and liquid chromatography coupled with single-stage mass spectrometry (LC-MS)). The relative ease of sample preparation, the ability to quantify metabolite levels, the high level of experimental reproducibility, and the inherently nondestructive nature of NMR spectroscopy have made it the preferred platform for long-term or large-scale clinical metabolomic studies. These advantages, however, are often outweighed by the fact that most other analytical techniques, including both LC-MS and GC-MS, are inherently more sensitive than NMR, with lower limits of detection typically being 10 to 100 times better. This review is intended to introduce readers to the field of NMR-based metabolomics and to highlight both the advantages and disadvantages of NMR spectroscopy for metabolomic studies. It will also explore some of the unique strengths of NMR-based metabolomics, particularly with regard to isotope selection/detection, mixture deconvolution via 2D spectroscopy, automation, and the ability to noninvasively analyze native tissue specimens. Finally, this review will highlight a number of emerging NMR techniques and technologies that are being used to strengthen its utility and overcome its inherent limitations in metabolomic applications.

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Section: New Nmr Methods In Metabolomicsmentioning

confidence: 99%

NMR Spectroscopy for Metabolomics Research

et al. 2019

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“…In case of functionalized PMMA, that is, PMED and PMPA shows the absorption band at 279 nm and 290 nm. The absorption bands of PMED and PMPA increases from pure PMMA due to functionalization with amino group 41 . The absorption band of TiO 2 NPs at 342 nm 42 .…”

Section: Resultsmentioning

confidence: 99%

“…The absorption bands of PMED and PMPA increases from pure PMMA due to functionalization with amino group. 41 The absorption band of TiO 2 NPs at 342 nm. 42 PMED1, PMED2, PMPA1, and PMPA2 shows two absorption bands at 280 nm, 280 nm, 291 nm, and 290 nm due to the presence of amino group and 348 nm, 352 nm, 347 nm, and 351 nm due to low percent of TiO 2 NPs.…”

Section: Uv-vis Studymentioning

confidence: 99%

Functionalization of PMMA/TiO₂ nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation

Singh

Mirza

Mondal

et al. 2021

J of Applied Polymer Sci

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The present work reports the functionalization of PMMA and its nanocomposites were synthesized via simple solution mixing method. Functionalization of PMMA with different amino containing groups, that is, ethylene diamine (ED) and 4‐amino benzoic acid (PA) and used with low dosage (1 wt% and 3 wt%) of TiO2 nanoparticles (NPs) to form nanocomposites. The morphology was determined by SEM, average particle size (50 nm) of TiO2 NPs was measured by TEM. The pore radius (14.47 A°) and specific surface area (157.89 m2/g) of TiO2 NPs were measured by BET analysis. FT‐IR and NMR analysis confirms the functionalization of PMMA. The antioxidant activity of functionalized PMMA and its nanocomposites have been analyzed by using 2,2 diphenyl‐1‐picryhydrazyl (DPPH) assay. The antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of functionalized polymer nanocomposites were investigated. The result revealed that functionalized PMMA (PMPA) shows maximum antioxidant activity. The increase in concentration of TiO2 NPs efficiently augments the bacterial inhibition against Gram‐negative and Gram‐positive bacteria. The maximum zone of inhibition (ZOI) was recorded against E. coli ATCC 25922 (30 mm) and S. aureus ATCC 29213 (31 mm) and minimum inhibitory concentration (MIC) over E. coli (64 μg/ml) and S. aureus (32 μg/ml) by PMPA2. The synthesized functionalized PMMA nanocomposites can be considered as promising material for biological applications.

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“…An electronic spectroscopic study of SCZ and the metal compounds in DMSO solution with a concentration of 10 −3 M was obtained by the Shimadzu UV/Vis spectrometer in the range of 200–1100 nm. The electron paramagnetic resonance study for the solid sample was recorded on a Bruker EMX PLUS spectrometer using the X band frequency (9.5 GHz) using reported experimental details ( Alahmari et al, 2019 ; Alghrably et al, 2019 ). The content of metal ions was calculated gravimetrically as metal oxides.…”

Section: Methodsmentioning

confidence: 99%

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

et al. 2021

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In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized. The chemical structure of each complex was characterized using elemental analysis (CHN), IR spectroscopy, UV–Vis spectroscopy, thermogravimetric analysis (TGA), and electronic paramagnetic resonance (EPR) spectroscopy. IR spectra indicated that the donor atoms were one sulfonyl oxygen atom and one pyrazine nitrogen atom, which associated with the metal ions to form a stable hexagonal coordination ring. The metal–ligand stability constant (Kf) revealed that Cu(II) and Ni(II) have good coordination stability among the metal compounds. Theoretical studies using DFT/B3LYP were performed to further validate the proposed structures. The obtained results indicated that Cu(II) has a trigonal bipyramidal geometry, whereas Fe(II), Co(II), and Ni(II) have an octahedral structure, while Zn(II) has a tetrahedral arrangement. The bio-activities of the characterized complexes were evaluated using DNA binding titration and molecular docking. The binding constant values for the metal complexes were promising, with a maximum value for the copper metal ion complex, which was 9 × 105 M-1. Molecular docking simulations were also carried out to evaluate the interaction strength and properties of the synthesized metal complexes with both DNA and selected cancer-relevant proteins. These results were supported by in vitro cytotoxicity assays showing that the Cu(II) and Ni(II) complexes display promising antitumor activity against colon and breast cancer cell lines.

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Tris(ethylenediamine)nickel(II) thio-hydroxogermanate monohydrate: Synthesis, crystal structure, 1H NMR, EPR, optical and magnetic properties

Cited by 15 publications

References 59 publications

NMR Spectroscopy for Metabolomics Research

NMR Spectroscopy for Metabolomics Research

Functionalization of PMMA/TiO₂ nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

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Tris(ethylenediamine)nickel(II) thio-hydroxogermanate monohydrate: Synthesis, crystal structure, 1H NMR, EPR, optical and magnetic properties

Cited by 15 publications

References 59 publications

NMR Spectroscopy for Metabolomics Research

NMR Spectroscopy for Metabolomics Research

Functionalization of PMMA/TiO2 nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies

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Functionalization of PMMA/TiO₂ nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation