Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

Abstract

The entitled organocatalyst is non‐toxic, cheap, bio‐degradable and easy to handle, and is used in the synthesis of pyran‐annulated heterocycles for the first time.

Brønsted-acid catalyzed cascade annulations toward the fused pyranoquinoline derivatives

“…7 Wadgaonkar et al developed an environmentally benign synthesis of pyran-annulated heterocycles using tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. 8 Nevertheless, the necessities of "prefunctionalization" of the starting materials are always problematic in the synthetic strategies. Since the substituted 4-hydroxyquinolones are not readily available and generally expensive from commercial source, thus deeply reduce the generality of the synthetic manipulations.…”

Sulfamic acid-catalyzed, environmentally benign synthesis of bis-tetronic acids at ambient temperature

“…Like multicomponent reactions, domino reactions also constitute a powerful synthetic strategy to introduce chemical and structural complexity. Among domino reactions, Knoevenagel-Michael reactions have emerged as a powerful strategy in the synthesis of various oxa-as well as aza-heterocycles [10][11][12][13].…”

An Amino Sugar Promoted Green Protocol: A One‐Pot, Meglumine‐Catalyzed, Multicomponent Strategy for Synthesis of Multifaceted Pyrroloacridin‐1(2H)‐one Derivatives

“…A range of both homogeneous as well as heterogeneous catalysts have been effectually used in most of the MCRs. Within this context, inquest for an environmentally benign synthesis of organic compounds by the use of a suitable catalyst is our next pursuit . The customary use of stoichiometric quantity of reagents is related to the generation of waste materials hence the shift of focus towards catalytic processes from stoichiometric methods has emerged as a necessity to enhance the effectiveness of synthetic protocols.…”