Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour

Bejenariu, Anca Gabriela; Popa, Marcel; Dulong, Virginie; Picton, Luc; Cerf, Didier Le

doi:10.1007/s00289-008-0033-8

Cited by 74 publications

(42 citation statements)

References 34 publications

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“…This factor generates electrostatic repulsions between the neighboring chains of the PVA and STMP, causing an increase of the swelling degree. 28 These data validate the results obtained by the analysis of the spectra of absorption in the infrared region and by DSC, wherein the decrease of the OH bond ( Figure 6) and increase of the temperature of the material degradation can be observed ( Figure 5). These results are verified by the reduction in the number of free hydroxyls due to the presence of reticulations, which also leads to a higher thermal resistance of the material.…”

Section: Discussionsupporting

confidence: 91%

Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

et al. 2015

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Hydrogels are polymeric materials with numerous medical and biological applications because of their physicochemical properties. In this context, the conditions were defined for obtaining a hydrogel with characteristics similar to the vitreous humor using polyvinyl alcohol (PVA) and trisodium trimetaphosphate (STMP). The concentration of PVA (X1 ), PVA/STMP ratio (X2 ), and initial pH (X3 ) were modified, and their effect was analyzed in terms of the refractive index (Y1 ), density (Y2 ), dynamic viscosity (Y3 ), and final pH (Y4 ). The results demonstrated that X1 interferes with Y1 , Y2 , and Y3 , and X2 interferes with Y2 and Y3 . The best condition for obtaining a hydrogel with characteristics similar to the vitreous humor was 4.2586% PVA (wt/wt), STMP/PVA ratio of 1:6.8213 (wt/wt), and initial pH of 9.424. DSC, ATR-FTIR, swelling degree, and AFM analysis confirmed the PVA reticulation with STMP. Furthermore, STMP increased the glass transition temperature and decreased the water uptake of ∼50% of the hydrogels, which can be explained by the crosslinking of PVA chains. Infrared spectroscopy revealed a decrease of hydroxyl bonds and confirmed the reticulation between PVA and STMP. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1386-1395, 2016.

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Section: Discussionsupporting

confidence: 91%

Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

et al. 2015

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“…The reaction produces amylose and/or xanthan gum pyrophosphate. Amylose and/or xanthan gum pyrophosphate may be attacked by an amylose hydroxyl group and/or xanthan gum, further resulting in amylose or di-xanthan gum phosphates [8].…”

Section: Discussionmentioning

confidence: 99%

“…The formulation of tablets with CL12-Ko-A-XG 1:2 (F5) excipients show the smallest expansion index value of 238.88%, whereas CL12-Ko-A-XG 1:1 (F4) and CL12-Ko-A-XG 2:1 (F6) have index values of 281.41% and 803.95%, respectively. This is due to the greater amount of xanthan gum, where xanthan gum has a good expanding index in the medium [8].…”

Section: Index Expands Tablet Formulamentioning

confidence: 99%

“…5), where tablets with excipient formulations having larger xanthan gum ratios have smaller expanding indices. Xanthan gum has a good expanding index in the medium so it can withstand a longer drug release [8].…”

Section: Drug Release (Dissolution) Testmentioning

confidence: 99%

“…If the xanthan gum is dysfunctional, the xanthan gum chain bond will become stronger. Cross-linking xanthan gum will make the macromolecule matrix stiff so that the index expands the declining tablets [8].…”

Section: Index Expands Tablet Formulamentioning

confidence: 99%

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Enzymatic Degradation of Cross-Linked Excipient Matrix of Co-Processed Xanthan Gum-Amylose and Dissolution Profile of Diclofenac Sodium Tablet

2017

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Objectives: This study aims to determine the amount of excipient that is degraded by alpha-amylase and the influence of alpha-amylase to the dissolution profile of sustained-release tablets that use matrix CL-Co-A-XG.Methods: Excipient is cross-linked with two concentrations of sodium trimetaphospate, which are 6% (CL6-Co-A-XG) and 12% (CL12-Co-A-XG). Each excipient is made with the ratios 1:1, 1:2, and 2:1 amylose-xanthan gum. Enzymatic degradation tests are performed on excipient powders for 60 minutes. Sustained-release tablet with CL-Co-A-XG excipient as a matrix is formulated through direct compression method. Then, drug dissolution tests are performed in a phosphate buffer with a pH of 7.4 both using and without using alpha-amylase as a medium for 8 hrs. Results:The results of this study show that CL6-Co-A-XG and CL12-Co-A-XG degraded 20% at 10 and 30 minutes, respectively. In addition, the release profile of F1-F6 tablets show the sustained-release profile that follows zero-order and Korsmeyer-Peppas kinetics and is unaffected by the presence of alpha-amylase. Conclusions:From this study, it can be concluded that the CL-Ko-A-XG excipients are more resistant to enzymatic degradation than amylose. Therefore, this excipient shows potential as a single matrix sustained-release tablet.

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Drug Delivery Systems Based on Xanthan

Atanase,

Popa

2024

Biopolymers in Pharmaceutical and Food Applications

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Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour

Cited by 74 publications

References 34 publications

Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

Enzymatic Degradation of Cross-Linked Excipient Matrix of Co-Processed Xanthan Gum-Amylose and Dissolution Profile of Diclofenac Sodium Tablet

Drug Delivery Systems Based on Xanthan

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