Trisomie 13 et hyperinsulinisme néonatal

Bellaton, Erianna; Aizenfisz, Sophie; Saizou, Carole; Baumann, Clarisse; Beaufils, F; Dauger, Stéphane

doi:10.1016/s0929-693x(02)00099-4

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A very high glucose infusion rate (22 mg/kg/min) was also required in this patient to keep normoglycemia for the first 19 days. The other case was a female infant with trisomy 13 reported by Bellaton et al [2002], developed hypoglycemia (blood glucose lavel, 12 mg/dl) without ketonuria immediately after birth and needed a very high glucose infusion rate (22 mg/kg/min) to keep normoglycemia. In all these three cases, symptomatic hypoglycemia was evident within 12 hr after birth.…”

Section: To the Editormentioning

confidence: 99%

Nylon 6/Brazilian clay membranes prepared by phase inversion

Leite

Maia

Araújo

et al. 2009

J of Applied Polymer Sci

View full text Add to dashboard Cite

Microporous membranes were synthesized from a polymer nanocomposite material, intercalated montmorillonite clay/nylon 6, by an immersion-precipitation method in a water bath. This membrane was skinless and was composed of cellular pores and sheaflike crystallites, which were interwoven into a bicontinuous structure. In contrast, pure nylon 6, precipitated under the same conditions, yielded a skinned asymmetric membrane. The X-ray diffraction patterns showed that the nanocomposites and the membranes exhibited exfoliated structures. By differential scanning calorimetry, it was observed that the clay probably acted as a reinforcing filler, increasing the crystallinity degree of the nanocomposites, but it was practically unchanged in the membranes. Through photomicrographs obtained by scanning electron microscopy, it was possible to verify that all the membranes exhibited an asymmetric morphology with a welldefined porous structure and a tight skin with a cellular sublayer.

show abstract

Section: To the Editormentioning

confidence: 99%

Nylon 6/Brazilian clay membranes prepared by phase inversion

Leite

Maia

Araújo

et al. 2009

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…A very high glucose infusion rate (22 mg/kg/min) was also required in this patient to keep normoglycemia for the first 19 days. The other case was a female infant with trisomy 13 reported by Bellaton et al [2002], developed hypoglycemia (blood glucose lavel, 12 mg/dl) without ketonuria immediately after birth and needed a very high glucose infusion rate (22 mg/ kg/min) to keep normoglycemia. In all these three cases, symptomatic hypoglycemia was evident within 12 hr after birth.…”

Section: Research Letter Hyperinsulinemic Hypoglycemia In a Newborn Imentioning

confidence: 99%

Hyperinsulinemic hypoglycemia in a newborn infant with trisomy 13

Tamame

Hori

Homma

et al. 2004

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Syndromic forms of congenital hyperinsulinism

2023

View full text Add to dashboard Cite

Congenital hyperinsulinism (CHI), also called hyperinsulinemic hypoglycemia (HH), is a very heterogeneous condition and represents the most common cause of severe and persistent hypoglycemia in infancy and childhood. The majority of cases in which a genetic cause can be identified have monogenic defects affecting pancreatic β-cells and their glucose-sensing system that regulates insulin secretion. However, CHI/HH has also been observed in a variety of syndromic disorders. The major categories of syndromes that have been found to be associated with CHI include overgrowth syndromes (e.g. Beckwith-Wiedemann and Sotos syndromes), chromosomal and monogenic developmental syndromes with postnatal growth failure (e.g. Turner, Kabuki, and Costello syndromes), congenital disorders of glycosylation, and syndromic channelopathies (e.g. Timothy syndrome). This article reviews syndromic conditions that have been asserted by the literature to be associated with CHI. We assess the evidence of the association, as well as the prevalence of CHI, its possible pathophysiology and its natural course in the respective conditions. In many of the CHI-associated syndromic conditions, the mechanism of dysregulation of glucose-sensing and insulin secretion is not completely understood and not directly related to known CHI genes. Moreover, in most of those syndromes the association seems to be inconsistent and the metabolic disturbance is transient. However, since neonatal hypoglycemia is an early sign of possible compromise in the newborn, which requires immediate diagnostic efforts and intervention, this symptom may be the first to bring a patient to medical attention. As a consequence, HH in a newborn or infant with associated congenital anomalies or additional medical issues remains a differential diagnostic challenge and may require a broad genetic workup.

show abstract

Trisomie 13 et hyperinsulinisme néonatal

Cited by 3 publications

References 8 publications

Nylon 6/Brazilian clay membranes prepared by phase inversion

Nylon 6/Brazilian clay membranes prepared by phase inversion

Hyperinsulinemic hypoglycemia in a newborn infant with trisomy 13

Syndromic forms of congenital hyperinsulinism

Contact Info

Product

Resources

About