Trisomy 11: prevalence among 22 403 unique patient cytogenetic studies and clinical correlates

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population‐based study from the Swedish AML registry

“…The proportion of AMLs with isolated gains increased quite dramatically by age, from 2.4% of all adult AML patients aged 60 years or younger to 23% of those over 60 years of age. Although we know of no other study with data on proportions of single trisomy‐positive AML in various age groups, the present result agrees well with Farag et al., who reported a significantly higher median age of AML patients with sole trisomies compared with other cases, and with several studies associating trisomies for chromosomes 8, 11, and 13 with high age . The reason(s) for this pronounced age‐related frequency difference, which is reminiscent of the increase of loss of 5q, 7q, and 17p and of monosomal and complex karyotypes by age in population‐based studies, is unknown.…”

“…The patients with +11 were characterized by a higher median age (71.5 years) than that of all other trisomy‐positive cases and IR patients (Tables and ), in correspondence with previous groups reporting an increased incidence of trisomy 11 in elderly patients . However, in contrast to some studies, most of our cases were de novo AML, i.e, had no prior history of myelodysplastic syndrome or exposure to chemo‐ and/or radiotherapy.…”

Adult Chronic Myelomonocytic Leukemia with Trisomy 11: A Case Report

“…Based on earlier studies, mds patients with trisomy 11 can be classified into high-or intermediate-risk groups 12 , but the prognostic value of trisomy 11 is better established for hematologic malignancies other than cmml 12,13 . In patients with acute myeloid leukemia, trisomy 11 is not uncommon and is associated with an intermediate or poor risk, with a median duration of complete remission of 17.5 months (range: 8.7-49.8 months), and with a median overall survival of 14.3 months (range: 0.5-50.7 months) 13 .…”

der(1)t(1;1)(p36;q11-q32) in hematopoietic malignancies

“…Two or several independent clones were found in 2 MPN (Caramazza et al, 2010;Duhoux et al, 2011) and 2 AML cases (Michalova et al, 1999;Chessells et al, 2002). Associated with chromosome 5 and/or 7 anomalies in 4 AML (Fugazza et al, 1997;PicosCardenas et al, 2002;Preiss et al, 2006;Duhoux et al, 2011) and with t(9;22)(q34;q11) in 1 CML (Phan et al 2006) and 2 ALL cases (Uckun etal 1998;Schmidt-Hieber et al 2010).…”

“…10 patients had lymphoid malignancies (8 ALL, 1 chronic lymphocytic leukemia (CLL) and 1 plasma cell leukemia (PCL) and there were 5 MM cases (Table 1). Chronic myeloproliferative neoplasms 5 patients: 1 polycythemia vera (PV) who progressed to myelofibrosis (MF) 27 years later (Duhoux et al, 2011), 1 chronic eosinophilic leukemia (CEL) (Duhoux et al, 2011), 1 chronic myeloid leukemia (CML) (Phan et al, 2006) and 2 patients with myelodysplastic syndrome (MDS) (Caramazza et al, 2010;Duhoux et al, 2011). Acute myeloid leukemia 14 patients, mainly with myelomonocytic-lineage: 1 acute myeloblastic leukemia with maturation (Fugazza et al, 1997), 2 acute myelomonocytic leukemia (Michalova et al, 1999;Duhoux et al, 2011), one of them progressed from MDS (Michalova et al, 1999).…”