Trisomy 18 in Kuwait

Naguib, Kamal K.; Al-Awadi, S A; Moussa, Mohamed; Bastaki, Lailá; Gouda, S.; Redha, M A; Mustafa, Fekriya E.; Tayel, Shawky; Abulhassan, S A; Murthy, D. S. Krishna

doi:10.1093/ije/28.4.711

Cited by 37 publications

(29 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,69 APA has not been found to be associated with trisomy 18. 70,71 Fathers of APA were less likely to sire offspring with trisomy 13 and no relationship has been shown between APA and the birth of an offspring with anencephaly or encephalocele. 69 With regard to Klinefelter syndrome, the population risk is around 1 in 500, 72 and one study found this to be increased to 1 in 312 in men of APA .50 years old.…”

Section: Effect Of Paternal Age On Offspring Healthmentioning

confidence: 95%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

View full text Add to dashboard Cite

Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

show abstract

Section: Effect Of Paternal Age On Offspring Healthmentioning

confidence: 95%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…The incidence of trisomy 18 in newborns is not affected by paternal age (Naguib et al, 1999), whereas fathers older than 39 years are less likely to have children with trisomy 13 (prevalence ratio 0.4, 95% CI: 0.16 -0.96) in comparison to fathers aged 25-29 years (Archer et al, 2007). Hatch et al (1990) evaluated autosomal trisomies (all autosomes except chromosome 1) in spontaneous miscarriages and found no significant paternal age effects (Hatch et al, 1990).…”

Section: Aneuploidiesmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

291

212

View full text Add to dashboard Cite

background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

show abstract

“…Patients with trisomy 18 have prenatal-onset severe growth retardation, characteristic craniofacial features, various visceral and skeletal malformations, and significant psychomotor mental retardation [Carey, 2001]. Several populationbased studies showed a remarkably reduced lifespan, with survival rates at age 1 year from 0 to 10% and with median survival time from 3 to 14.5 days [Carter et al, 1985;Young et al, 1986;Goldstein and Nielsen, 1988;Root and Carey, 1994;Embleton et al, 1996;Naguib et al, 1999;Nembhard et al, 2001;Brewer et al, 2002;Rasmussen et al, 2003]. The major causes of death were reported to be apnea and withdrawal of treatment [Embleton et al, 1996], and the presence of a congenital heart defect did not seem be associated with early death [Embleton et al, 1996;Rasmussen et al, 2003].…”

Section: Introductionmentioning

confidence: 99%

Neonatal management of trisomy 18: Clinical details of 24 patients receiving intensive treatment

Kosho

Nakamura

Kawame

et al. 2006

American J of Med Genetics Pt A

176

200

View full text Add to dashboard Cite

Management of neonates with trisomy 18 is controversial, supposedly due to the prognosis and the lack of precise clinical information concerning efficacy of treatment. To delineate the natural history of trisomy 18 managed under intensive treatment, we reviewed detailed clinical data of 24 patients with full trisomy 18 admitted to the neonatal intensive care unit of Nagano Children's Hospital, providing intensive treatment to those with trisomy 18, from 1994 to 2003. Cesarean, resuscitation by intubation, and surgical operations were performed on 16 (67%), 15 (63%), and 10 (42%) of the patients, respectively. Mechanical ventilation was required by 21 (88%), and 6 (29%) of them were extubated. Survival rate at age 1 week, 1 month, and 1 year was 88%, 83%, and 25%, respectively. Median survival time was 152.5 days. Respiration was not stabilized in two patients with left diaphragmatic eventration and hypoplasia accompanied by lung hypoplasia, even with maximal ventilation. The common underlying factors associated with death were congenital heart defects and heart failure (96%), followed by pulmonary hypertension (78%). The common final modes of death were sudden cardiac or cardiopulmonary arrest (26%) and possible progressive pulmonary hypertension-related events (26%). These data of improved survival, through neonatal intensive treatment, are helpful for clinicians to offer the best information on treatment options to families of patients with trisomy 18. ß 2006 Wiley-Liss, Inc.

show abstract

Trisomy 18 in Kuwait

Abstract: Trisomy 18 birth prevalence rate is high in Kuwait with advanced maternal age as a significant risk factor.

Cited by 37 publications

References 25 publications

The effects of advanced paternal age on fertility

The effects of advanced paternal age on fertility

Paternal age and reproduction

Neonatal management of trisomy 18: Clinical details of 24 patients receiving intensive treatment

Contact Info

Product

Resources

About