Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

Paulsson, Kajsa; Johansson, Bertil

doi:10.1016/j.patbio.2006.04.007

Cited by 91 publications

(91 citation statements)

References 153 publications

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“…16 Moreover, other data indicated that þ 8 AML showed no specific gene expression signature. 2 In conclusion, our retrospective data show that allo-HSCT is an effective treatment for AML patients harboring þ 8. The addition of other chromosomal abnormalities to þ 8 seems to influence the outcomes of these patients compared with AML patients with isolated þ 8.…”

Section: Discussionmentioning

confidence: 64%

“…On the other hand, as already reported, patients bearing þ 8 in addition to another abnormality from the 'good-risk' or the 'high-risk' groups may have the prognosis conferred by the accompanying cytogenetic aberration. 2 Nevertheless, because of the small number of patients involved, these results have to be taken with caution.…”

Section: Discussionmentioning

confidence: 98%

“…It is rather accepted that þ 8 is an important event, but not sufficient for leukemogenesis, as several studies have indicated that þ 8 is not the primary event involved in malignant transformation. 2 It is also admitted that the Myc gene located at 8q24 is not a target of þ 8 as Myc in þ 8 AML is down-regulated. 16 Moreover, other data indicated that þ 8 AML showed no specific gene expression signature.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prognostic effect of þ 8 as a sole chromosomal abnormality in AML remains debated and was found in the literature to be associated either with an intermediate or a poor prognosis. [1][2][3] The results of the Medical Research Council-AML10 trial has assigned AML patients with isolated þ 8 in the 'intermediate' cytogenetic abnormality risk group, showing a 3-year OS and relapse risk of 42 and 42%, respectively. This study suggested also a worsened outcome for these patients in comparison with other cytogenetic abnormality risk group categories within this heterogeneous 'intermediate' prognosis group.…”

Section: Introductionmentioning

confidence: 99%

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Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT

Chevallier

Labopin

Nagler

et al. 2009

Bone Marrow Transplant

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The aim of this multicenter retrospective analysis was to carry out a survey of overall outcomes after allohematopoietic SCT of AML patients harboring trisomy 8 (þ 8) as the sole chromosomal abnormality or associated with other abnormalities. We have identified 182 de novo AML patients who underwent allo-hematopoietic SCT between 1990 and 2007 exhibiting isolatedor unknown (n ¼ 1) cytogenetic abnormalities reported to the European Group of Blood and Marrow Transplantation (EBMT). With a median follow-up of 48 months, 5-year non-relapse mortality, relapse rate, leukemia-free survival and OS were 25, 30, 45 and 47%, respectively. In a multivariate analysis, leukemia-free survival rate was improved when patients were female and transplanted in CR with an HLA-identical sibling donor. Five-year leukemia-free survival was 41, 88, 57 and 21% in patients bearing isolated þ 8 or þ 8 and other cytogenetic abnormalities of good, intermediate or poor-risk, respectively. Our retrospective data show that allo-hematopoietic SCT is an effective treatment for AML patients harboring þ 8. The accompanying cytogenetic abnormality to þ 8 seems to influence outcomes of these patients.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT

Chevallier

Labopin

Nagler

et al. 2009

Bone Marrow Transplant

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“…A variety of hematological diseases are connected with trisomy 8, indicating a non-specific role in leukemia pathogenesis. The prognostic impact of trisomy 8 as the sole change in AML and MDS is discussed controversial in the literature [16][17][18][19]. However, another frequent cytogenetic abnormality involving chromosome 8, the reciprocal translocation t(8;21) usually correlates with AML-M2 and indicate a good prognosis [20].…”

Section: Introductionmentioning

confidence: 99%

Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia?

Lier¹,

Junker²,

Kempf³

et al. 2012

Biodiscovery

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The impact of chromosome architecture in the formation of chromosome aberrations is a recent finding of interphase directed molecular cytogenetic studies. There evidence was provided that disease specific chromosomal translocations could be due to tissue specific genomic organization. In a recent small pilot study using three-dimensional interphase fluorescence in situ hybridization, we showed that there might be a specific chromosome positioning in myeloid bone marrow cells, i.e. a co-localization of chromosomes 8 and 21. Here we could substantiate this finding in overall 21 studied cases with acute myeloid leukemia (AML) that there is even a co-localization of the genes AML1 and ETO. This finding led to the suggestion that a specific interphase architecture of myeloid bone marrow cells might promote the typical t(8;21)(q22;q22) leading to AML-M2.

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Acute Myeloid Leukemia

Johansson¹,

Harrison²

2010

Cancer Cytogenetics

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Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

Cited by 91 publications

References 153 publications

Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT

Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT

Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia?

Acute Myeloid Leukemia

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