Trissel’s Stability of Compounded Formulations, 6e

ASPEN Safe Practices for Enteral Nutrition Therapy

“…For a medication administered enterally to be absorbed, it must first be dissolved in solution. Preparing a liquid dosage form is fraught with complexities, and an appropriate reference should be consulted before assuming stability 17 . ‐ 21 Even simple operations such as crushing an immediate‐release tablet and mixing it with water must be examined because the safety and efficacy of the medication may be affected by the quality of the water (tap vs purified), degree of crushing (particle size), and time of exposure (as the drug may degrade in a liquid form).…”

Sedation and Analgesia Using Medications Delivered via the Extravascular Route in Children Undergoing Laceration Repair

“…This could be secondary to the pH of midazolam, which is more acidic (3), whereas the pH of ketamine (3.5-5.5) and the pH of dexmedetomidine (4.5-7) are less acidic. 19,20 One potential solution that has been described in the literature is the use of 10 mg of lidocaine spray prior to IN midazolam with MADs to prevent discomfort. 21 N 2 O is also inhaled as a gas mixture with oxygen, and hence has a very quick onset time, but children younger than 5 years may not tolerate the use of a facemask, which is needed to ef-fectively deliver the gas mixture.…”

Evidencing the impact of drug store storage conditions on the quality and stability of amoxicillin powders for oral suspension marketed in Peru

“…Os produtos para uso oral contendo amoxicilina devem ser armazenados em frascos bem vedados, à temperatura ambiente controlada. Temperatura elevada e umidade podem levar à hidrólise da amoxicilina, ocorrendo clivagem hidrolítica do anel beta-lactâmico com formação do ácido amoxicilóico (Trissel, 2009;Ferreira, 2007).…”