2011
DOI: 10.1074/jbc.m110.202275
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Tristetraprolin-dependent Post-transcriptional Regulation of Inflammatory Cytokine mRNA Expression by Apolipoprotein A-I

Abstract: Atherosclerosis is an inflammatory disease characterized by the accumulation of macrophages in the arterial intima. The activated macrophages secreted more pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-␣, which promote the development of the disease. Apolipoprotein A-I (apoA-I), the major component of high density lipoprotein, is involved in reverse cholesterol transport of lipid metabolism. Recently, it has been found that apoA-I suppresses inflammation via repression of inflammatory cytokin… Show more

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Cited by 54 publications
(28 citation statements)
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“…Silencing of ABCA1 expression in human macrophages indicates that only the action of IL-6 on IL-1␤ secretion may be dependent on ABCA1 as this latter was abolished in ABCA1 KD macrophages. Previous studies described ABCA1 as an antiinflammatory receptor through the interaction of apoAI with ABCA1 and subsequent activation of the Jak2/Stat-3 signaling pathway (13,14). Although human macrophages do not express apoAI, such an effect occurs in vitro when THP-1 macrophages are incubated in the presence of apoAI (14).…”
Section: Discussionmentioning
confidence: 97%
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“…Silencing of ABCA1 expression in human macrophages indicates that only the action of IL-6 on IL-1␤ secretion may be dependent on ABCA1 as this latter was abolished in ABCA1 KD macrophages. Previous studies described ABCA1 as an antiinflammatory receptor through the interaction of apoAI with ABCA1 and subsequent activation of the Jak2/Stat-3 signaling pathway (13,14). Although human macrophages do not express apoAI, such an effect occurs in vitro when THP-1 macrophages are incubated in the presence of apoAI (14).…”
Section: Discussionmentioning
confidence: 97%
“…Although human macrophages do not express apoAI, such an effect occurs in vitro when THP-1 macrophages are incubated in the presence of apoAI (14). Thus, the addition of exogenous apoAI to THP-1 macrophages strongly attenuated the stimulation of proinflammatory cytokines secretion, such as IL-1␤, observed upon LPS treatment (14). The requirement of ABCA1 in the inhibitory effect of IL-6 on IL-1␤ secretion may, therefore, result from the induction of ABCA1 expression by IL-6 in THP-1 macrophages, which would favor interaction of ABCA1 not with apoAI, which was not present in our experimental conditions, but potentially with apoE, which is abundantly expressed by human macrophages and was largely described to interact with ABCA1 for promoting cellular cholesterol efflux.…”
Section: Discussionmentioning
confidence: 99%
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“…The expression, phosphorylation, and subcellular localization of TTP, together with interactions of TTP with other proteins, are closely related to the occurrence and development of malignant tumors, suggesting that TTP expression and dysfunction are an important indicator of cancer development (Sanduja et al, 2012). The expression of TTP can be induced by many factors, including insulin (Cao et al, 2008), mitogen (Hitti et al, 2006), apolipoprotein (Yin et al, 2011), and green tea (Cao et al, 2007). The upregulation of TTP has been found to inhibit the development of inflammation, atherosclerosis, and some malignancies (Yin et al, 2009).…”
Section: Introductionmentioning
confidence: 99%