Triterpene Saponins from Branches of Pinus massoniana

Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity

“…17 isolated from the branches and needles of P. massoniana have been reported. 18,19 In an effort to find natural potential PDE4 inhibitors, five previously undescribed compounds (1−5), including two diterpenoids, one norditerpenoid, and two trinorditerpenoids, along with 27 known substances were isolated from the root bark of P. massoniana, and the PDE4D inhibitory effects of most isolates were evaluated. Herein, the isolation and structural identification of these compounds and their PDE4D inhibitory activities are reported.…”

“…Phytochemical research on Pinus species has led to the isolation of compounds representing diverse classes, including triterpenoids, diterpenoids, flavonoids, lignans, and phenols. − Pinus massoniana Lamb., a tall evergreen plant, is widespread in central and south regions of mainland China, and its needles, pollen, bark, resin, and turpentine have been used for the treatment of cancer, rheumatic arthritis, arthralgia, dermatitis rhus, and inflammation. − Diterpenoids, the main secondary metabolites of Pinus species, were also isolated from P. massoniana resin and reported to possess cytotoxicity against A431 and A549 cancer cells . Moreover, two triterpenoid saponins and two sesquiterpenoid glycosides isolated from the branches and needles of P. massoniana have been reported. , In an effort to find natural potential PDE4 inhibitors, five previously undescribed compounds ( 1 – 5 ), including two diterpenoids, one norditerpenoid, and two trinorditerpenoids, along with 27 known substances were isolated from the root bark of P. massoniana , and the PDE4D inhibitory effects of most isolates were evaluated. Herein, the isolation and structural identification of these compounds and their PDE4D inhibitory activities are reported.…”