Triterpene Saponins from <i>Cyclamen mirabile</i> and Their Biological Activities

Caliş, T; Me, Satana; Yürüker, Ayşen; Kelican, P; Demirdamar, R.; Alaçam, R; Tanker, Nevin; Rüegger, Heinz; Sticher, Otto

doi:10.1021/np960658j

Cited by 32 publications

(16 citation statements)

References 6 publications

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“…Wächter and coworkers demonstrated poor antitubercular activity of OA-derivatives isolated from Lippia turbinata (Verbenaceae), with MIC values varying from 64 mg mL -1 to 128 mg mL -1 [49]. Caliş and coworkers did not observe any antimicrobial activity of OA isolated from Cyclamen mirabile (Primulaceae) against Gram-positive (S. aureus and E. faecalis) and Gram-negative (P. aeruginosa and E. coli) species [50]. The antimicrobial constituents of Gentianopsis paludosa (Gentianaceae), the plant used in local Tibetan medicine to treat pneumonia, diarrhea and several other diseases were recently investigated and found to include OA, which when purified, was inactive against Mycobacterium smegmatis (MIC>500 mg mL -1 ) and M. tuberculosis (MIC>128 mg mL -1 ) [51].…”

Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used antibiotics are no longer effective.Thus, there is considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic acid (UA) and their derivatives. These compounds can be isolated from many medicinal and crop plants and their antibacterial, antiviral, antiulcer and anti-inflammatory effects are well documented. OA and UA are active against many bacterial species, particularly Gram-positive species, including mycobacteria. They inhibit bacterial growth and survival, and the spectrum of minimal inhibitory concentration (MIC) values is very broad. In addition, OA, UA and their derivatives display potent antimutagenic activity. Studies to identify the cellular targets and molecular mechanisms of OA and UA action were initiated a few years ago and it has already been demonstrated that both acids influence bacterial gene expression, the formation and maintenance of biofilms, cell autolysis and peptidoglycan turnover. Before these compounds can be used clinically as antimicrobial agents, further extensive studies are required to determine their cytotoxicity and the optimum mode of their application.

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Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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“…Cyclamen tubers have been used in the folk medicine for their sedative, purgative, antihelmintic, laxative, and abortive properties (Speroni et al, 2007). Different extracts of Cyclamen tubers were shown to possess cytotoxic, antimicrobial, spermicidal, analgesic, and anti-inflammatory activities (Ç aliş et al, 1997;Dall'Acqua et al, 2010;Kupchan et al, 1967;Mahasneh & El-Oqlah, 1999;Primorac et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

Hosry

Giorgio

Birer

et al. 2014

Pharmaceutical Biology

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Context: The genus Cyclamen L. (Primulaceae) is rich in saponins known to have interesting biological activities. Objective: To isolate saxifragifolin B and cyclamin, two triterpene saponins, from Cyclamen libanoticum Hildebr and Cyclamen persicum Mill, and to assess their cytotoxic, clastogenic/ aneugenic, and anticlastogenic effects, as well as antioxidant potential. Materials and methods: Saxifragifolin B and cyclamin were tested for their cytotoxicity against SK-BR-3, HT-29, HepG2/3A, NCI-H1299, BXPC-3, 22RV1, and normal DMEM cell lines using WST-1 assay. Their clastogenic/aneugenic activities and anticlastogenic effects against the anticancer drug mitomycin C were assessed by the in vitro micronucleus assay in CHO cells. Their antioxidant capacities were determined using Fe 2+ -chelating and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assays. Results: Both saponins were described for the first time in Cyclamen libanoticum. They showed strong cytotoxic activities against the tested cancer cell lines. Saxifragifolin B was found to be 56-and 37-times more active than mitomycin C against breast adenocarcinoma (SK-BR-3) and lung carcinoma (NCI-H1299), respectively. Also, saxifragifolin B did not induce micronuclei formation and prevented cells from mitomycin C clastogenic effect. Cyclamin induced a significant increase of micronucleated cells after metabolic activation with S9 mix, and did not possess any anticlastogenic activity. Both molecules exhibited low antioxidant activities as compared to reference compounds. Discussion and conclusions: This study showed the remarkable cytotoxic activity of saxifragifolin B, especially against breast adenocarcinoma and lung carcinoma and its chemoprotective activity against mitomycin C. Thus, saxifragifolin B could be suggested as a potential cytotoxic drug with a preventive effect against possible exposures to genotoxic agents.

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“…These metabolites include the flavonoids, phenols and phenolic glycosides, saponins, cyanogenic glycosides, unsaturated lactones and glucosinolates [5–8]. In the past, herbs often represented the original sources of most drugs and herbal remedies, but nowadays, alternative medicines are used widely in all over the world [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Eleucine indica Possesses Antioxidant, Antibacterial and Cytotoxic Properties

Al-Zubairi

Abdul

Abdelwahab

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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The use of evidence-based complementary and alternative medicine is increasing rapidly. Eleucine indica (EI) is traditionally used in ailments associated with liver and kidneys. The therapeutic benefit of the medicinal plants is often attributed to their antioxidant properties. Therefore, the aim of this study was to screen the hexane, dicholoromethane, ethyl acetate (EA) and methanol extracts (MeTH) of EI for their antioxidant, antibacterial and anti-cancer effects using total phenolic contents (TPCs) and DPPH, disc diffusion method and MTT cytotoxicity assays, respectively. The MeTH was showed to have the highest TPC and scavenging activity (77.7%) on DPPH assay, followed by EA (64.5%), hexane (47.19%) and DCM (40.83%) extracts, whereas the MeTH showed no inhibitory effect on all tested bacteria strains. However, the EA extract exhibited a broad spectrum antibacterial activity against all tested bacteria except Bacillus subtilis, in which this bacterium was found to be resistant to all EI extracts. Meanwhile, hexane extract was demonstrated to have a remarkable antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, while the dicholoromethane extract did not exhibit significant activity against P. aeruginosa. None of the extracts showed significant cytotoxic activity towards MCF-7, HT-29 and CEM-SS human cancer cell lines after 72 h incubation time (IC50 > 30 μg/ml). These results demonstrate that the extract prepared from the EI possesses antioxidant activity in vitro in addition to antibacterial properties. Further investigations are needed to verify the antioxidant effects in vitro and in vivo.

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Triterpene Saponins from Cyclamen mirabile and Their Biological Activities

Cited by 32 publications

References 6 publications

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Antibacterial activity of oleanolic and ursolic acids and their derivatives

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

Eleucine indica Possesses Antioxidant, Antibacterial and Cytotoxic Properties

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