Triterpene saponins from Silphium radula

Calabria, Lalita M.; Piacente, Sonia; Kapusta, Ireneusz; Dharmawardhane, Suranganie; Segarra, Frances M.; Pessiki, Peter J.; Mabry, Tom J.

doi:10.1016/j.phytochem.2007.10.017

Cited by 20 publications

(20 citation statements)

References 28 publications

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“…(Asteraceae)(urs-12-ene-3β,6β,6β-triol-3- O -β-Gal-(1 → 2)-β-GlcMDA-MB-23125 μg ml −1 (80% inhib. )PI; antiproliferativeCalabria et al (2008) Synapta maculata (Synaptida, Apodida)Synaptoside AHeLa IC 50 [μg ml l −1 ] 8.6MTS; cytotoxicAvilov et al (2008) Synthetic betulinic acid derivatives 16 compounds; most potent: 1- O -[3-β-acetoxy-lup-20(29)-ene-28-oyl]-α- d -Mann IC 50 [μmol l −1 ] Calcein AMFluorescent viability; cytotoxicCmoch et al (2008)CEM10.4MCF 722.7A-54943.3HeLa34.7BJ-H-tert38.7RPMI 822619.4G 36122.7Control: betulinic acidCEM40MCF 7>50A-549>50…”

Section: Cytotoxic Saponins (2005–2009)mentioning

confidence: 99%

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Saponins as cytotoxic agents: a review

2010

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Saponins are natural glycosides which possess a wide range of pharmacological properties including cytotoxic activity. In this review, the recent studies (2005–2009) concerning the cytotoxic activity of saponins have been summarized. The correlations between the structure and the cytotoxicity of both steroid and triterpenoid saponins have been described as well as the most common mechanisms of action.

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Section: Cytotoxic Saponins (2005–2009)mentioning

confidence: 99%

“…Moreover, the authors suggested that a monodesmosidic disaccharide chain containing a galactopyranosyl residue produces higher activity than bidesmosidic or monodesmosidic single sugar moiety (Calabria et al 2008). …”

Section: Correlation Between the Structure And Cytotoxicity Of Saponinsmentioning

confidence: 99%

Saponins as cytotoxic agents: a review

2010

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“…Its molecular formula was assigned to be C 30 C-NMR spectrum revealed 30 carbon signals, which were further classified by DEPT and HSQC experiments as six methyls, 10 methylenes (one oxygenated), eight methines (two oxygenated), six quaternary carbons (including one carboxyl group) ( Table 1). The aforementioned data implied that 1 was an ursane-28-oic-acid with three hydroxyls [10][11][12][13][14][15].…”

Section: Resultsmentioning

confidence: 99%

Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii

et al. 2013

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3α,6α, 3α,6α,7α,, together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1-3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.

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“…Extensive phytochemical investigation has been realized regarding the natural occurrence of triterpenoids [10][11][12][13][14][15][16], anthraquinones and indole alkaloids [17][18][19][20] in the family. Rubiaceae family plants exhibited antimalarial, antimicrobial, antihypertension, antidiabetic, antioxidant, and anti-inflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Urosilic Acid from Knoxia corymbosa

R¹,

Ramakrishna²,

K³

et al. 2017

Nat Prod Chem Res

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Air-dried, milled leaves of Knoxia corymbosa (220 gm) were extracted repeatedly with dichloromethane. After removal of solvent in vacuo, the CH 2 Cl 2 -solvent residue was fractionated by using hexane and ethyl acetate solvents. After fractionation, all fractions are submitted for NMR spectroscopy. Out of all fractions interesting fractions are subjected to column chromatography, so that we isolated one pure compound as Ursolic acid which is a known compound as it is characterized by using reference data. This is the first time to be isolated the above compound from this species. Ursolic acid is a five-membered cyclic triterpenoid compound. A structure of the isolated compound has been assigned on the basis of their analytical data. By surveying the literature, we came to understand that the compound ursolic acid is a cyclic five-member triterpenoid first to be isolated from Knoxia corymbosa. And also, it is first time to isolate the above compound from this species Knoxia corymbosa.

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Triterpene saponins from Silphium radula

Cited by 20 publications

References 28 publications

Saponins as cytotoxic agents: a review

Saponins as cytotoxic agents: a review

Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii

Isolation of Urosilic Acid from Knoxia corymbosa

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